PHR1335

Supelco

Labetalol Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Labetalol hydrochloride, 2-Hydroxy-5-[1-hydroxy-2-[(1-methyl-3-phenylpropyl)amino]ethyl]benzamide hydrochloride
Empirical Formula (Hill Notation):
C19H24N2O3 · HCl
CAS Number:
Molecular Weight:
364.87
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

form

neat

CofA

current certificate can be downloaded

application(s)

HPLC: suitable
gas chromatography (GC): suitable

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to BP L0050000
traceable to USP 1356654

SMILES string

Cl.CC(CCc1ccccc1)NCC(O)c2ccc(O)c(c2)C(N)=O

InChI

1S/C19H24N2O3.ClH/c1-13(7-8-14-5-3-2-4-6-14)21-12-18(23)15-9-10-17(22)16(11-15)19(20)24;/h2-6,9-11,13,18,21-23H,7-8,12H2,1H3,(H2,20,24);1H

InChI key

WQVZLXWQESQGIF-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152), ADRB1(153), ADRB2(154), ADRB3(155)

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General description

Labetalol Hydrochloride is an adrenergic α-receptor and β-receptor blocking agent, widely used in the treatment of hypertension. It is a sensitive drug and is used quantitatively especially in myocardial infarction and unstable angina, since it decreases blood pressure more rapidly than other beta blockers.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Labetalol Hydrochloride may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric techniques.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA1069 in the slot below. This is an example certificate only and may not be the lot that you receive.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Determination of labetalol hydrochloride by kinetic spectrophotometry using potassium permanganate as oxidant
Rahman N, et al.
Journal of the Mexican Chemical Society, 55(2), 105-112 (2011)
Determination of labetalol hydrochloride in drug formulations by spectrophotometry
Rahman N, et al.
J. Chin. Chem. Soc., 54(1), 185-196 (2007)

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