PHR1402

Phenoxybenzamine Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride, Phenoxybenzamine hydrochloride
• Empirical Formula (Hill Notation): C₁₈H₂₂ClNO · HCl
• CAS Number: 63-92-3
• Molecular Weight: 340.29
• EC Number: 200-569-7
• MDL number: MFCD00055152
• PubChem Substance ID: 329823375
• NACRES: NA.24

Properties

• Quality Level: 300
• grade: certified reference material; pharmaceutical secondary standard
• Agency: traceable to USP 1526007
• CofA: current certificate can be downloaded
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: Cl[H].CC(COc1ccccc1)N(CCCl)Cc2ccccc2
• InChI: 1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H
• InChI key: VBCPVIWPDJVHAN-UHFFFAOYSA-N
• Gene Information: human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Description

General description

Phenoxybenzamine Hydrochloride is an important drug belonging to the class of β-chloroethylamine drugs. It functions as an α-blocker by binding to α-adrenoreceptors, located on vascular smooth muscles and stops the influence of sympathetic nerves on blood vessels. It is widely used in the treatment of hypertension, benign prostatic hyperplasia and hypoplastic left heart syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Phenoxybenzamine Hydrochloride may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic and chemiluminescence techniques.

Biochem/physiol Actions

Calmodulin antagonist; α-adrenoceptor antagonist.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA2196 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Pictograms: GHS07,GHS08
• Signal Word: Warning
• Hazard Statements: H302 - H351
• Precautionary Statements: P201 - P301 + P312 + P330 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Carc. 2
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable