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PHR1402

Supelco

Phenoxybenzamine Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride, Phenoxybenzamine hydrochloride
Empirical Formula (Hill Notation):
C18H22ClNO · HCl
CAS Number:
Molecular Weight:
340.29
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

Agency

traceable to USP 1526007

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Cl[H].CC(COc1ccccc1)N(CCCl)Cc2ccccc2

InChI

1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H

InChI key

VBCPVIWPDJVHAN-UHFFFAOYSA-N

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General description

Phenoxybenzamine Hydrochloride is an important drug belonging to the class of β-chloroethylamine drugs. It functions as an α-blocker by binding to α-adrenoreceptors, located on vascular smooth muscles and stops the influence of sympathetic nerves on blood vessels. It is widely used in the treatment of hypertension, benign prostatic hyperplasia and hypoplastic left heart syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Phenoxybenzamine Hydrochloride may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations by chromatographic and chemiluminescence techniques.

Biochem/physiol Actions

Calmodulin antagonist; α-adrenoceptor antagonist.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA2196 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation markHealth hazard

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Enter Lot Number to search for Certificate of Analysis (COA).

Certificate of Origin

Enter Lot Number to search for Certificate of Origin (COO).

More Documents

Quotes and Ordering

Sensitive chemiluminescence determination of phentolamine mesylate and phenoxybenzamine hydrochloride based on K3Fe (CN) 6-H2O2-fluorescein
Xing L, et al.
Journal of Luminescence, 137(38), 162-167 (2013)
Quantitative gas chromatographic determination of azapetine and phenoxybenzamine in pharmaceutical preparations
Silvestri S and Taponeco G
Journal of Chromatography A, 37(38), 200-204 (1968)
A facile enantioselective synthesis of enantiomerically pure (R)-phenoxybenzamine hydrochloride using the hydrolytic kinetic resolution method
Nikalje MD, et al.
Tetrahedron Asymmetry, 21(23), 2825-2829 (2010)
Chiral aziridine ring opening: facile synthesis of (R)-mexiletine and (R)-phenoxybenzamine hydrochloride
Viswanadh N, et al.
Tetrahedron Letters, 56(38), 5269-5271 (2015)
Phenoxybenzamine and phenoxybenzamine hydrochloride.
IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, 24, 185-194 (1980-01-01)

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