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PHR1434

Supelco

Sodium Metabisulfite

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Sodium metabisulfite, Sodium disulfite, Sodium pyrosulfite
Linear Formula:
Na2S2O5
CAS Number:
Molecular Weight:
190.11
EC Number:
MDL number:
PubChem Substance ID:

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to USP 1614396

API family

sodium metabisulfite

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

>300 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

[Na+].[Na+].[O-]S(=O)S([O-])(=O)=O

InChI

1S/2Na.H2O5S2/c;;1-6(2)7(3,4)5/h;;(H,1,2)(H,3,4,5)/q2*+1;/p-2

InChI key

HRZFUMHJMZEROT-UHFFFAOYSA-L

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This Item
13459PHR1800PHR1068
Sodium Metabisulfite Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1434

Sodium Metabisulfite

-
Sodium metabisulfite puriss., meets analytical specification of Ph. Eur., BP, NF, FCC, E223, dry, 97-100.5%

Sigma-Aldrich

13459

Sodium metabisulfite

Essential Grade
Supelco

Supelco

PHR1800

Metamizole Sodium

-
technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

-

format

-

format

neat

storage temp.

2-30°C

storage temp.

-

storage temp.

2-8°C

storage temp.

2-30°C

Quality Level

300

Quality Level

200

Quality Level

300

Quality Level

300

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. Sodium Metabisulfite is a sulfiting agent, widely employed as antioxidants, preservatives and browning inhibitors in pharmaceutical formulations and a variety of food and beverages.

Application

Sodium Metabisulfite may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using amperometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2953 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1

Supplementary Hazards

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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25G
Pack Size/Quantity

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Amperometric quantification of sodium metabisulfite in pharmaceutical formulations utilizing tetraruthenated porphyrin film modified electrodes and batch injection analysis.
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Sulfites, preservatives and antioxidants used in the cosmetic, pharmaceutical and food industry are contact allergens whose relevance seems to be difficult to establish. To perform a retrospective study on patients patch tested with a sulfite. Materials and methods. Between 1990
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