PHR1434

Supelco

Sodium Metabisulfite

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Sodium disulfite, Sodium pyrosulfite, Sodium metabisulfite
Linear Formula:
Na2S2O5
CAS Number:
Molecular Weight:
190.11
EC Number:
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

application(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

>300 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1614396

SMILES string

[Na+].[Na+].[O-]S(=O)S([O-])(=O)=O

InChI

1S/2Na.H2O5S2/c;;1-6(2)7(3,4)5/h;;(H,1,2)(H,3,4,5)/q2*+1;/p-2

InChI key

HRZFUMHJMZEROT-UHFFFAOYSA-L

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General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. Sodium Metabisulfite is a sulfiting agent, widely employed as antioxidants, preservatives and browning inhibitors in pharmaceutical formulations and a variety of food and beverages.

Application

Sodium Metabisulfite may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using amperometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2953 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Statements

Supp Hazards

EUH031

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
Amperometric quantification of sodium metabisulfite in pharmaceutical formulations utilizing tetraruthenated porphyrin film modified electrodes and batch injection analysis.
Quintino MSM, et al.
Talanta, 68(4), 1281-1286 (2006)
Juan García-Gavín et al.
Contact dermatitis, 67(5), 260-269 (2012-10-09)
Sulfites, preservatives and antioxidants used in the cosmetic, pharmaceutical and food industry are contact allergens whose relevance seems to be difficult to establish. To perform a retrospective study on patients patch tested with a sulfite. Materials and methods. Between 1990...
Ping Chu et al.
PLoS pathogens, 10(10), e1004439-e1004439 (2014-10-24)
Francisella tularensis causes the disease tularemia. Human pulmonary exposure to the most virulent form, F. tularensis subsp. tularensis (Ftt), leads to high morbidity and mortality, resulting in this bacterium being classified as a potential biothreat agent. However, a closely-related species...
Natalia Mosconi et al.
ChemMedChem, 9(6), 1211-1220 (2014-05-09)
We report the synthesis, characterization, antibacterial and antifungal activities, phytotoxicity, and genotoxicity of two new complexes of silver(I) with sulfachloropyridazine (SCP), one of which is heteroleptic with SCP and SCN(-) ligands (Ag-SCP-SCN), the other of which is homoleptic (Ag-SCP); furthermore...
Sarah Bradbury et al.
Addiction biology, 19(5), 874-884 (2013-06-15)
The current study aimed to elucidate the role of pharmacokinetic (PK) parameters and neurotransmitter efflux in explaining variability in (±) 3, 4-methylenedioxymethamphetamine (MDMA) self-administration in rats. PK profiles of MDMA and its major metabolites were determined after the administration of...

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