PHR1520

Supelco

Chlortetracycline Hydrochloride

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
7-Chlorotetracycline hydrochloride, Chlortetracycline hydrochloride
Empirical Formula (Hill Notation):
C22H23ClN2O8 · HCl
CAS Number:
Molecular Weight:
515.34
Beilstein/REAXYS Number:
3858364
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

application(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

210-215 °C (dec.) (lit.)

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to BP 783
traceable to PhEur C2000000
traceable to USP 1129007

SMILES string

Cl.CN(C)[C@H]1[C@@H]2CC3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O

InChI

1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7?,8-,15-,21-,22-;/m0./s1

Inchi Key

CBHYYLPALVVVEY-LYNLVHCPSA-N

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General description

Chlortetracycline Hydrochloride is a salt of chlortetracycline, which is a tetracycline which shows broad-spectrum antibiotic activity. It is generally used as a veterinary and aquaculture medicine. It is often used on dairy cattle and aquacultured catfish, salmon, and lobster.
Pharmaceutical secondary standard for application in quality control. Provides pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Chlortetracycline may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by spectrophotometry technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC3430 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Target Organs

Respiratory system

RIDADR

NONH for all modes of transport

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
The spectrophotometric assay for chlortetracycline HCl and tetracycline HCl in pharmaceuticals
Chiccarelli FS, et al.
Journal of the American Pharmaceutical Association, 48(5), 263-268 (1959)
Determination of tetracycline residues in shrimp and whole milk using liquid chromatography with ultraviolet detection and residue confirmation by mass spectrometry
Andersen WC, et al.
Analytica Chimica Acta, 529(1-2), 145-150 (2005)

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