PHR1555

Hexane

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Hexane, n-Hexane
• Linear Formula: CH₃(CH₂)₄CH₃
• CAS Number: 110-54-3
• Molecular Weight: 86.18
• UNSPSC Code: 41116107
• NACRES: NA.24
• PubChem Substance ID: 329823464
• EC Number: 203-777-6
• Beilstein/REAXYS Number: 1730733
• MDL number: MFCD00009520

Properties

• Quality Level: 300
• grade: certified reference material, pharmaceutical secondary standard
• agency: traceable to USP 1601601
• vapor density: ~3 (vs air)
• vapor pressure: 256 mmHg ( 37.7 °C), 5.2 psi ( 37.7 °C), ~132 mmHg ( 20 °C)
• CofA: current certificate can be downloaded
• autoignition temp.: 453 °F
• expl. lim.: 7.7 %
• packaging: ampule of 3x1.2 mL
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• refractive index: n20/D 1.375 (lit.)
• bp: 69 °C (lit.)
• mp: −95 °C (lit.)
• density: 0.659 g/mL at 25 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: CCCCCC
• InChI: 1S/C6H14/c1-3-5-6-4-2/h3-6H2,1-2H3
• InChI key: VLKZOEOYAKHREP-UHFFFAOYSA-N

Description

General description

Hexane is a non-polar organic solvent and a straight-chain alkane with six carbon atoms. It belongs to the Class 2 category of organic solvents, as per United States Pharmacopoeia. It has limited application in the synthesis of pharmaceuticals, due to its moderate toxicity.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Hexane may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by gas chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAB5023 in the slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• pictograms: GHS02,GHS08,GHS07,GHS09
• signalword: Danger
• hcodes: H225,H304,H315,H336,H361f,H372,H411
• pcodes: P202 - P210 - P273 - P301 + P310 - P303 + P361 + P353 - P331
• Hazard Classifications: Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Inhalation - STOT SE 3
• target_organs: Central nervous system, Nervous system
• Storage Class: 3 - Flammable liquids
• flash_point_f: -7.6 °F - closed cup
• flash_point_c: -22 °C - closed cup