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PHR1555

Supelco

Hexane

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Hexane, n-Hexane
Linear Formula:
CH3(CH2)4CH3
CAS Number:
Molecular Weight:
86.18
Beilstein:
1730733
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to USP 1601601

vapor density

~3 (vs air)

vapor pressure

256 mmHg ( 37.7 °C)
5.2 psi ( 37.7 °C)
~132 mmHg ( 20 °C)

CofA

current certificate can be downloaded

autoignition temp.

453 °F

expl. lim.

7.7 %

packaging

ampule of 3x1.2 mL

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.375 (lit.)

bp

69 °C (lit.)

mp

−95 °C (lit.)

density

0.659 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

CCCCCC

InChI

1S/C6H14/c1-3-5-6-4-2/h3-6H2,1-2H3

InChI key

VLKZOEOYAKHREP-UHFFFAOYSA-N

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This Item
RTC000084675393650552
Hexane Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1555

Hexane

Hexane Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

RTC000084

Hexane

Hexane HPLC Plus, for HPLC, GC, and residue analysis, ≥95%

Sigma-Aldrich

675393

Hexane

Hexane HPLC Plus, for HPLC, GC, and residue analysis, ≥95%

Sigma-Aldrich

650552

Hexane

packaging

ampule of 3x1.2 mL

packaging

pkg of 20 mL

packaging

-

packaging

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

application(s)

food and beverages

format

neat

format

-

format

-

format

-

storage temp.

2-30°C

storage temp.

2-30°C

storage temp.

-

storage temp.

-

General description

Hexane is a non-polar organic solvent and a straight-chain alkane with six carbon atoms. It belongs to the Class 2 category of organic solvents, as per United States Pharmacopoeia. It has limited application in the synthesis of pharmaceuticals, due to its moderate toxicity.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Hexane may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by gas chromatography.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB5023 in the slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Signal Word

Danger

Hazard Classifications

Aquatic Chronic 2 - Asp. Tox. 1 - Flam. Liq. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2 Inhalation - STOT SE 3

Target Organs

Central nervous system, Nervous system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

-7.6 °F

Flash Point(C)

-22 °C


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?467? Residual Solvents
USP43/NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia/National Formulary, 45(3)(9), 6712-6712 (2019)
Green process chemistry in the pharmaceutical industry
Cue BW and Zhang J
Green Chemistry Letters and Reviews, 2(4), 193-211 (2009)
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Capello C, et al.
Green Chemistry, 9(9), 927-934 (2007)
A generic static headspace gas chromatography method for determination of residual solvents in drug substance.
Cheng, et al.
Journal of Chromatography A, 1217(41), 6413-6421 (2010)

Protocols

Separation of Hexane; Heptane; Octane; Nonane; Decane; Undecane; Dodecane; Tetradecane; Hexadecane; Octadecane; Eicosane; Tetracosane; Octacosane; Dotriacontane; Hexatriacontane; Tetracontane; Tetratetracontane

Protocol for GC Analysis of Hydrocarbons in Gasoline on Petrocol® DH

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