PHR1578

Supelco

Trolamine

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Triethanolamine, Tris(2-hydroxyethyl)amine, 2,2′,2′′-Nitrilotriethanol
Linear Formula:
(HOCH2CH2)3N
CAS Number:
Molecular Weight:
149.19
Beilstein/REAXYS Number:
1699263
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

5.14 (vs air)

vapor pressure

0.01 mmHg ( 20 °C)

CofA

current certificate can be downloaded

autoignition temp.

600 °F

expl. lim.

8.5 %

packaging

ampule of 5 mL

application(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.485 (lit.)

useful pH range

7.3 - 8.3

pKa (25 °C)

7.8

bp

190-193 °C/5 mmHg (lit.)

mp

17.9-21 °C (lit.)

density

1.124 g/mL at 25 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to PhEur T2545000
traceable to USP 1696958

SMILES string

OCCN(CCO)CCO

InChI

1S/C6H15NO3/c8-4-1-7(2-5-9)3-6-10/h8-10H,1-6H2

InChI key

GSEJCLTVZPLZKY-UHFFFAOYSA-N

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standard. Trolamine belongs to the family of ethanolamines, offering a broad spectrum of applications due to its ability to combine the properties of both amines and alcohols. Its property as an organic base to form soluble neutralization products with insoluble acids is reported.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC2885 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

354.2 °F - closed cup

Flash Point(C)

179 °C - closed cup

The Preparation of Emulsions and Other Products with Triethanolamine N(C2H4OH)3, 1-86 (1933)
Toxicology of Mono-, Di-, and Triethanolamine
Knaak BJ, et al.
Reviews of Environmental Contamination and Toxicology, 1-86 (1997)

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