PHR1588

Supelco

Piroxicam

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
4-Hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2H-1,2-benzothiazine 1,1-dioxide, Piroxicam
Empirical Formula (Hill Notation):
C15H13N3O4S
CAS Number:
Molecular Weight:
331.35
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

packaging

pkg of 200 mg

application(s)

HPLC: suitable
gas chromatography (GC): suitable

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to PhEur P2130000
traceable to USP 1544508

SMILES string

CN1C(C(=O)Nc2ccccn2)=C(O)c3ccccc3S1(=O)=O

InChI

1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20)

InChI key

QYSPLQLAKJAUJT-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742), PTGS2(5743)

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General description

Piroxicam belongs to the class of acidic, non-steroid anti-inflammatory (NSAI) drugs, with a long half-life which enables it to be administered once daily.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Piroxicam may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and urine by spectrophotometry.

Biochem/physiol Actions

Cyclooxygenase inhibitor.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA4573 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Skull and crossbonesHealth hazard

Signal Word

Danger

Hazard Statements

Target Organs

Gastrointestinal tract

RIDADR

UN 2811 6.1 / PGIII

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
A simple spectrofluorimetric method for determination of piroxicam and propranolol in pharmaceutical preparations.
Tabrizi AB
Journal of food and drug analysis, 15(3) (2007)
Anal. Profiles Drug Subst., 15, 509-531 (1986)
Spectrophotometric determination of piroxicam and tenoxicam in pharmaceutical formulations using alizarin.
Amin AS
Journal of Pharmaceutical and Biomedical Analysis, 29(4), 729-736 (2002)
Sensitive spectrophotometric methods for the determination of amoxycillin, ciprofloxacin and piroxicam in pure and pharmaceutical formulations.
Nagaralli BS, et al.
Journal of Pharmaceutical and Biomedical Analysis, 29(5), 859-864 (2002)
Determination of piroxicam in pharmaceutical formulations and urine samples using europium-sensitized luminescence.
Al-Kindy SMZ, et al.
Journal of Luminescence, 127(2), 291-296 (2007)

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