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PHR1666

Supelco

Diethyl Ether

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Ethyl ether, Ether, Diethyl ether
Linear Formula:
(CH3CH2)2O
CAS Number:
Molecular Weight:
74.12
Beilstein:
1696894
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

2.6 (vs air)

CofA

current certificate can be downloaded

autoignition temp.

320 °F

quality

pharmaceutical secondary standard

expl. lim.

36.5 %

packaging

pkg of 3 × 1.2 mL

application(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.3530 (lit.)

bp

34.6 °C (lit.)

mp

−116 °C (lit.)

density

0.706 g/mL at 25 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)

format

neat

SMILES string

CCOCC

InChI

1S/C4H10O/c1-3-5-4-2/h3-4H2,1-2H3

InChI key

RTZKZFJDLAIYFH-UHFFFAOYSA-N

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General description

Diethyl ether is a non-polar volatile organic solvent, commonly used as an extraction solvent in liquid-liquid extraction for separation of post reaction residues from synthetic products.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Diethyl ether may be used as a solvent reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by gas chromatography.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0145 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

FlameExclamation mark

Signal Word

Danger

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Flam. Liq. 1 - STOT SE 3

Target Organs

Central nervous system

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK Germany

WGK 1

Flash Point(F)

-40.0 °F - closed cup

Flash Point(C)

-40 °C - closed cup

Certificate of Analysis

Certificate of Origin

Residual solvent testing: a review of gas-chromatographic and alternative techniques
B'Hymer C
Pharmaceutical Research, 20(3), 337-344 (2003)
Determination of residual solvent levels in bulk pharmaceuticals by capillary gas chromatography
Smith ID and Waters DG
Analyst, 116(12), 1327-1331 (1991)
Organic solvents in the pharmaceutical industry
Grodowska K and Parczewski A
Acta Poloniae Pharmaceutica, 67(1), 3-12 (2010)

Articles

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Protocols

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