PHR1687

Cyclohexane

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Cyclohexane
• Empirical Formula (Hill Notation): C₆H₁₂
• CAS Number: 110-82-7
• Molecular Weight: 84.16
• Beilstein: 1900225
• EC Number: 203-806-2
• MDL number: MFCD00003814
• PubChem Substance ID: 329823556
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• Agency: traceable to USP 1601408
• vapor density: 2.9 (vs air)
• vapor pressure: 168.8 mmHg ( 37.7 °C); 77 mmHg ( 20 °C)
• CofA: current certificate can be downloaded
• autoignition temp.: 500 °F
• expl. lim.: 9 %
• packaging: ampule of 3x1.2 mL
• technique(s): HPLC: suitable; gas chromatography (GC): suitable
• refractive index: n20/D 1.426 (lit.)
• bp: 80.7 °C (lit.)
• mp: 4-7 °C (lit.)
• density: 0.779 g/mL at 25 °C (lit.)
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: C1CCCCC1
• InChI: 1S/C6H12/c1-2-4-6-5-3-1/h1-6H2
• InChI key: XDTMQSROBMDMFD-UHFFFAOYSA-N

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Cyclohexane is a nonpolar, flammable liquid that belongs to the group of cycloalkanes. In general, cyclohexane is obtained by hydrogenation of benzene and predominately used in the nylon industry. It also finds application in pharmaceutical applications.

Application

Cyclohexane can be used as a pharmaceutical reference standard for residual solvent analysis in pharmaceutical formulations and raw materials by gas chromatography.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0291 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• Pictograms: GHS02,GHS07,GHS08,GHS09
• Signal Word: Danger
• Hazard Statements: H225 - H304 - H315 - H336 - H410
• Precautionary Statements: P210 - P233 - P273 - P301 + P310 - P303 + P361 + P353 - P331
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Asp. Tox. 1 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Central nervous system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): -4.0 °F - closed cup
• Flash Point(C): -20 °C - closed cup