PHR1687

Supelco

Cyclohexane

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
Cyclohexane
Empirical Formula (Hill Notation):
C6H12
CAS Number:
Molecular Weight:
84.16
Beilstein/REAXYS Number:
1900225
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.24
Pricing and availability is not currently available.

Quality Level

grade

certified reference material
pharmaceutical secondary standard

vapor density

2.9 (vs air)

vapor pressure

168.8 mmHg ( 37.7 °C)
77 mmHg ( 20 °C)

CofA

current certificate can be downloaded

autoignition temp.

500 °F

expl. lim.

9 %

packaging

ampule of 3x1.2 mL

application(s)

HPLC: suitable
gas chromatography (GC): suitable

refractive index

n20/D 1.426 (lit.)

bp

80.7 °C (lit.)

mp

4-7 °C (lit.)

density

0.779 g/mL at 25 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1601408

SMILES string

C1CCCCC1

InChI

1S/C6H12/c1-2-4-6-5-3-1/h1-6H2

InChI key

XDTMQSROBMDMFD-UHFFFAOYSA-N

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Cyclohexane is a nonpolar, flammable liquid that belongs to the group of cycloalkanes. In general, cyclohexane is obtained by hydrogenation of benzene and predominately used in the nylon industry. It also finds application in pharmaceutical applications.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Cyclohexane can be used as a pharmaceutical reference standard for residual solvent analysis in pharmaceutical formulations and raw materials by gas chromatography.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0291 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Signal Word

Danger

Target Organs

Central nervous system

RIDADR

UN1145 - class 3 - PG 2 - Cyclohexane

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Residual solvents determination in drug products by static headspace-gas chromatography
Camarasu CC
Chromatographia, 56(1), S137-S143 (2002)
Pervaporation: Membrane Separations
Encyclopedia of Separation Science, 3636-3641 (2000)
Validation of a generic analytical procedure for determination of residual solvents in drug substances
Klick S and Skold A
Journal of Pharmaceutical and Biomedical Analysis, 36(2), 401-409 (2004)
Organic solvents in the pharmaceutical industry
Grodowska K and Parczewski A
Acta Poloniae Pharmaceutica, 67(1), 3-12 (2010)

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