This product is not tested for solubility and is intended for use as an analytical standard. However, this compound is typically soluble in water at 20 mg/mL. Various sources note that this material is also soluble in DMSO, no concentration is provided. In general, DMSO, at a final concentration of less than 0.5%, is not expected to have a negative impact on cells.
PHR1700
Ribavirin
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
Ribavirin, 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
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1 G
$153.00
$153.00
Estimated to ship onJanuary 09, 2026fromMILWAUKEE
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About This Item
Empirical Formula (Hill Notation):
C8H12N4O5
CAS Number:
Molecular Weight:
244.20
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
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grade
certified reference material
pharmaceutical secondary standard
Quality Level
agency
traceable to Ph. Eur.
traceable to USP 1602706
API family
ribavirin
CofA
current certificate can be downloaded
packaging
pkg of 1 g
technique(s)
HPLC: suitable
gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-8°C
SMILES string
NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
InChI
1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
InChI key
IWUCXVSUMQZMFG-AFCXAGJDSA-N
Gene Information
human ... IMPDH1(3614)
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1 of 4
This Item | Y0000377 | BP593 | 1602706 |
|---|---|---|---|
| technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) - | technique(s) - |
| format neat | format neat | format neat | format neat |
| Quality Level 300 | Quality Level - | Quality Level - | Quality Level - |
| grade certified reference material, pharmaceutical secondary standard | grade pharmaceutical primary standard | grade pharmaceutical primary standard | grade pharmaceutical primary standard |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| packaging pkg of 1 g | packaging - | packaging - | packaging - |
General description
Analog of the imidazole nucleotide intermediates in purine nucleotide biosynthesis.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards
Ribavirin is a synthetic guanosine analog, effective against respiratory syncytial virus, several hemorrhagic fever viruses and human immuno deficiency virus.[1]Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
Application
Ribavirin may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by high-pressure liquid chromatographic method.[2]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions
Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase, but many other mechanisms of action are also supported with experimental evidence.
Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA6966 in the slot below. This is an example certificate only and may not be the lot that you receive.
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signalword
Danger
hcodes
Hazard Classifications
Muta. 2 - Repr. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Stability-Indicating HPLC-DAD Determination of Ribavirin in Capsules and Plasma.
Haggag RS, et al.
Journal of Chromatographic Science, 52(6), 493-500 (2013)
Intravenous ribavirin and hyperammonemia in an immunocompromised patient infected with adenovirus.
Bertrand P, et al.
Pharmacotherapy, 20(10), 1216-1220 (2000)
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