PHR1733

Escitalopram Oxalate

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Escitalopram oxalate, S-(+)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile oxalate, S-(+)-Citalopram oxalate
• Empirical Formula (Hill Notation): C₂₀H₂₁FN₂O · C₂H₂O₄
• CAS Number: 219861-08-2
• Molecular Weight: 414.43
• NACRES: NA.24
• PubChem Substance ID: 329823581
• UNSPSC Code: 41116107
• MDL number: MFCD06407826

Properties

• Quality Segment: 300
• grade: certified reference material, pharmaceutical secondary standard
• agency: traceable to Ph. Eur. Y0001796, traceable to USP 1249406
• API family: escitalopram
• CofA: current certificate can be downloaded
• packaging: pkg of 1 g
• technique(s): HPLC: suitable, gas chromatography (GC): suitable
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-30°C
• SMILES string: OC(=O)C(O)=O.CN(C)CCC[C@]1(OCc2cc(ccc12)C#N)c3ccc(F)cc3
• InChI: 1S/C20H21FN2O.C2H2O4/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;3-1(4)2(5)6/h4-9,12H,3,10-11,14H2,1-2H3;(H,3,4)(H,5,6)/t20-;/m0./s1
• InChI key: KTGRHKOEFSJQNS-BDQAORGHSA-N
• Gene Information: human ... SLC6A4(6532)

Description

General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Escitalopram Oxalate, a highly selective serotonin re-uptake inhibitor antidepressant, is a pure S-enantiomer of the racemic, bicyclic pthalates derivatives of citalopram. It is mainly developed for the treatment of depression and anxiety disorders.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Escitalopram Oxalate may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance thin layer chromatography technique and reversed-phase high-performance liquid chromatography technique.

Biochem/physiol Actions

Escitalopram is a selective serotonin reuptake inhibitor (SSRI), the S-enantiomer and eutomer of citalopram.

Escitalopram oxalate is a selective serotonin reuptake inhibitor (SSRI); the S-enantiomer and eutomer of citalopram.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC2085 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302 + H312
• pcodes: P264 - P280 - P301 + P312 - P302 + P352 + P312 - P362 + P364 - P501
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable