PHR1746

Supelco

4-Aminosalicylic acid

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):
4-Amino-2-hydroxybenzoic acid, PAS, 4-Aminosalicylic acid
Linear Formula:
H2NC6H3-2-(OH)CO2H
CAS Number:
Molecular Weight:
153.14
Beilstein/REAXYS Number:
473071
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

grade

certified reference material
pharmaceutical secondary standard

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

application(s)

HPLC: suitable
gas chromatography (GC): suitable

mp

135-145 °C (lit.)

Featured Industry

Pharmaceutical (small molecule)

format

neat

pharmacopeia traceability

traceable to USP 1026401

SMILES string

Nc1ccc(C(O)=O)c(O)c1

InChI

1S/C7H7NO3/c8-4-1-2-5(7(10)11)6(9)3-4/h1-3,9H,8H2,(H,10,11)

InChI key

WUBBRNOQWQTFEX-UHFFFAOYSA-N

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General description

4-Aminosalicylic acid is an isomer of 5-ASA, the active component of sulfasalazine. This nonsteroidal anti-inflammatory drug (NSAID) has been used in the treatment of tuberculosis and is also known to be effective in treating distal ulcerative colitis.
Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA7969 in the slot below. This is an example certificate only and may not be the lot that you receive.

storage_class_code

11 - Combustible Solids

WGK Germany

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Placebo-controlled trial of ulcerative colitis with oral 4-aminosalicylic acid
Ginsberg AL, et al.
Gastroenterology, 102(2), 448-452 (1992)

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