The compound is soluble in DMSO at 2.5 mg/ml and in DMF (Dimethyl formamide) at 5 mg/ml. The solvent used should be purged with inert gas. It is soluble at approximately 0.5 mg/ml in a 1:1 solution of DMF:PBS at pH 7.2 prepared by dissolving initially in DMF and then adding to PBS. Use the solution within one day.
PHR1757
Nevirapine
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
Nevirapine, 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3,2-b:2′,3′-e][1,4]diazepin-6-one
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1 G
$153.00
$153.00
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About This Item
Empirical Formula (Hill Notation):
C15H14N4O
CAS Number:
Molecular Weight:
266.30
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:
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Quality Level
grade
certified reference material, pharmaceutical secondary standard
agency
traceable to Ph. Eur. Y0000520, traceable to USP 1460703
API family
nevirapine
CofA
current certificate can be downloaded
packaging
pkg of 1 g
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
application(s)
pharmaceutical (small molecule)
format
neat
storage temp.
2-30°C
SMILES string
CC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O
InChI
1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
InChI key
NQDJXKOVJZTUJA-UHFFFAOYSA-N
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This Item | |||
|---|---|---|---|
| application(s) pharmaceutical (small molecule) | application(s) pharmaceutical | application(s) - | application(s) pharmaceutical (small molecule) |
| technique(s) HPLC: suitable, gas chromatography (GC): suitable | technique(s) - | technique(s) - | technique(s) - |
| format neat | format neat | format - | format neat |
| Quality Level 300 | Quality Level - | Quality Level 100 | Quality Level - |
| grade certified reference material, pharmaceutical secondary standard | grade pharmaceutical primary standard | grade - | grade pharmaceutical primary standard |
| storage temp. 2-30°C | storage temp. 2-8°C | storage temp. room temp | storage temp. 2-8°C |
General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI), which belongs to the class of antiretroviral drugs. It acts by inhibiting the reverse transcriptase enzyme, thus suppressing the multiplication of HIV. It is highly effective against the advanced HIV disease.
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Nevirapine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and fixed dose combinations by chromatography.
Biochem/physiol Actions
NNRTI (non-nucleoside reverse transcriptase inhibitor) of HIV-1
Nevirapine is an allosteric, non-nucleoside inhibitor of HIV reverse transcriptase (NNRTI). The Ki for inhibition of wild-type RT by Nevirapine is 200 nM.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Other Notes
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA8118 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
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Product No.
Description
Pricing
Storage Class
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
MEKC determination of antiretroviral reverse transcriptase inhibitors lamivudine, stavudine, and nevirapine in pharmaceutical formulations
Sekar R and Azhaguvel S
Chromatographia, 67(5-6), 389-398 (2008)
Nevirapine
USP42-NF37
United States Pharmacopeia/National Formulary, 32(3), 3101-3101 (2018)
Simultaneous determination of lamivudine, stavudine and nevirapine in antiretroviral fixed dose combinations by high performance liquid chromatography
Kapoor N, et al.
Analytica Chimica Acta, 570(1), 41-45 (2006)
Development and validation of a simple and rapid capillary zone electrophoresis method for determination of nnrti nevirapine in pharmaceutical formulations
Zanolli F, et al.
Journal of the Brazilian Chemical Society, 22(10), 2005-2012 (2011)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| PHR1757-1G | 04061834802341 |
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