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PHR1784

Supelco

Aripiprazole

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Aripiprazole, 7-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butoxy}-3,4-dihydro-2(1H)-quinolinone
Empirical Formula (Hill Notation):
C23H27Cl2N3O2
CAS Number:
Molecular Weight:
448.39

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to Ph. Eur. Y0001649
traceable to USP 1042634

API family

aripiprazole

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

InChI

1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)

InChI key

CEUORZQYGODEFX-UHFFFAOYSA-N

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PHR2321PHR2322PHR2323
Supelco

Supelco

PHR1784

Aripiprazole

packaging

pkg of 500 mg

packaging

pkg of 100 mg

packaging

pkg of 100 mg

packaging

pkg of 100 mg

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

-

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

pharmaceutical

application(s)

-

format

neat

format

-

format

-

format

-

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aripiprazole is a benzisoxazole derivative and second-generation antipsychotic and anti-depressant drug. It is used in the management of schizophrenia and bipolar I disorder. It shows partial agonistic activity towards dopamine D2 and serotonin 5-HT1A receptors and antagonistic activity at 5-HT2A receptors.

Application

This pharmaceutical secondary standard can also be used as follows:
  • Development of a reversed phase-high-performance liquid chromatography (RP-HPLC) method for the determination of aripiprazole in the presence of nine of its impurities in both bulk and its pharmaceutical formulations
  • Direct voltammetric determination of aripiprazole in pharmaceutical formulations, human serum, and urine samples
  • Simultaneous estimation of aripiprazole and octoclothepin in pharmaceutical formulations and human urine samples by two different voltammetric methods using glassy carbon electrodes
  • UV-spectroscopic determination of aripiprazole in pure and tablet formulations following ICH guidelines
  • Multi-analysis of aripiprazole, clozapine, and sulpiride in pharmaceutical formulations and biological fluids by extraction-free UV-Visible spectrophotometric methods based on the ability of the three antipsychotic drugs to form stable ion-pair complexes with bromophenol blue (BPB) and bromothymol blue (BTB)

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0259 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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T1503
Product Number
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25G
Pack Size/Quantity

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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

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Development and validation of UV spectrophotometric determination of aripiprazole in bulk and tablet formulation
Patle HS, et al.
International Journal of Current Pharmaceutical Research , 3, 59-61 (2011)
Spectrophotometric determination of aripiprazole, clozapine and sulpiride by ion-pair extractionin in tablets and biological fluids
Eldidamony AM, et al.
International Journal of Pharmacy and Pharmaceutical Sciences, 7, 178-184 (2014)
Validation of an HPLC method for determination of aripiprazole and its impurities in pharmaceuticals
Djordjevic F, et al.
Acta Chromatographica , 1, 13-28 (2014)
Electrochemistry and analytical determination of aripiprazole and octoclothepin at glassy carbon electrode
Merli D, et al.
Journal of Electroanalytical Chemistry, 711, 1-7 (2013)
Fabien Ducrocq et al.
Cell metabolism, 31(4), 755-772 (2020-03-07)
Reward-processing impairment is a common symptomatic dimension of several psychiatric disorders. However, whether the underlying pathological mechanisms are common is unknown. Herein, we asked if the decrease in the n-3 polyunsaturated fatty acid (PUFA) lipid species, consistently described in these

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