PHR1796

Imipenem

Name: Imipenem
Brand: SIAL
Price: 246 USD

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Imipenem monohydrate, (5R,6S)-6-[(1R)-1-Hydroxyethyl]-3-[[2-[(iminomethyl)amino]ethyl]thio]-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid monohydrate, Primaxin monohydrate, Tienam monohydrate

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200 MG

$246.00

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₇N₃O₄S · H₂O

CAS Number:

74431-23-5

Molecular Weight:

317.36

NACRES:

NA.24

PubChem Substance ID:

329823620

UNSPSC Code:

41116107

EC Number:

264-734-5

MDL number:

MFCD09753321

Key Documents

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Product Name

Imipenem, Pharmaceutical Secondary Standard; Certified Reference Material

InChI key

GSOSVVULSKVSLQ-JJVRHELESA-N

InChI

1S/C12H17N3O4S.H2O/c1-6(16)9-7-4-8(20-3-2-14-5-13)10(12(18)19)15(7)11(9)17;/h5-7,9,16H,2-4H2,1H3,(H2,13,14)(H,18,19);1H2/t6-,7-,9-;/m1./s1

SMILES string

O.C[C@@H](O)[C@@H]1[C@H]2CC(SCCNC=N)=C(N2C1=O)C(O)=O

grade

certified reference material
pharmaceutical secondary standard

agency

traceable to Ph. Eur. I0090000
traceable to USP 1337809

API family

imipenem

form

solid

CofA

current certificate can be downloaded

packaging

pkg of 200 mg

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

storage temp.

-10 to -25°C

Quality Level

300

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Related Categories

Analytical Reference Materials for Pharma QC

Certified Reference Materials

Pharmacopeia & Metrological Institute Standards

Reference Materials

Analytical Chemistry

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Show Differences

1 of 4

This Item	PHR1772	PHR1805	PHR1044
Supelco PHR1796 Imipenem	Supelco PHR1772 Meropenem	Supelco PHR1805 Piperacillin	Supelco PHR1044 Ciprofloxacin HCl
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable	technique(s) HPLC: suitable, gas chromatography (GC): suitable
form solid	form -	form -	form -
Quality Level 300	Quality Level 300	Quality Level 300	Quality Level 300
grade certified reference material, pharmaceutical secondary standard	grade certified reference material, pharmaceutical secondary standard	grade certified reference material, pharmaceutical secondary standard	grade certified reference material, pharmaceutical secondary standard
storage temp. -10 to -25°C	storage temp. 2-8°C	storage temp. -10 to -25°C	storage temp. 2-30°C

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Application

Imipenem may be used as a pharmaceutical reference standard for the quantification of the analyte in biological samples[1][2] and pharmaceutical formulations by various analytical techniques.

Biochem/physiol Actions

Imipenem monohydrate is a broad spectrum B-lactam antibiotic.

Imipenem monohydrate is a broad spectrum B-lactam antibiotic. It is a member of the carbapenem class of "magic bullet" antibiotics for severe infections.

General description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Imipenem belongs to the class of carbapenems, a beta-lactam antibiotic, effective against aerobic and anaerobic bacteria. Carbapenems act by inhibiting the peptidoglycan synthesis involved in bacterial cell wall formation, thus causing the death of the target microorganism.[3]

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAC0262 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

comparable product

Product No.

Description

Pricing

1337809

Imipenem monohydrate, United States Pharmacopeia (USP) Reference Standard

I0090000

Imipenem, European Pharmacopoeia (EP) Reference Standard

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Find documentation for the products that you have recently purchased in the Document Library.

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Comparative Evaluation of Broth Microdilution with Polystyrene and Glass-Coated Plates, Agar Dilution, E-Test, Vitek, and Disk Diffusion for Susceptibility Testing of Colistin and Polymyxin B on Carbapenem-Resistant Clinical Isolates of Acinetobacter baumannii.

Lipika Singhal et al.

Microbial drug resistance (Larchmont, N.Y.), 24(8), 1082-1088 (2018-02-07)

With the increasing threat of multidrug-resistant organisms, such as Acinetobacter baumannii, the polymyxin class of drugs (colistin and polymyxin B) has become popular in clinical practice. A better understanding of antimicrobial susceptibility testing methods for colistin and polymyxin B is

Neurokinin-1 Receptor Deficiency Improves Survival in Murine Polymicrobial Sepsis Through Multiple Mechanisms in Aged Mice.

Juan R Mella et al.

Shock (Augusta, Ga.), 52(1), 61-66 (2018-08-11)

Substance P (SP) is a neuropeptide that contributes to a proinflammatory state by binding to the neurokinin 1 receptor (NK-1R). Limiting this interaction has been shown to attenuate the acute inflammation. Our hypothesis was that NK-1R activation would contribute to

Reversible inactivation of a peptidoglycan transpeptidase by a β-lactam antibiotic mediated by β-lactam-ring recyclization in the enzyme active site.

Zainab Edoo et al.

Scientific reports, 7(1), 9136-9136 (2017-08-24)

β-lactam antibiotics act as suicide substrates of transpeptidases responsible for the last cross-linking step of peptidoglycan synthesis in the bacterial cell wall. Nucleophilic attack of the β-lactam carbonyl by the catalytic residue (Ser or Cys) of transpeptidases results in the

Determination of imipenem in plasma by high-performance liquid chromatography for pharmacokinetic studies in patients

Garcia-Capdevila L, et al.

Journal of Chromatography. B, Biomedical Sciences and Applications, 692(1), 127- 132 (1997)

Stability-indicating HPLC method development and validation for simultane-ous determination of cilastatin and imipenem in pharmaceutical dosage forms

Kishore MS and Rambabu C

International Journal of Research in Pharmaceutical Sciences, 8(4), 560-567 (2017)

View All Related Papers

Questions

1–3 of 3 Questions

Anonymous

6 months ago

How can I determine the shelf life / expiration / retest date of this product?

1 answer
1. Technical Support
  
  6 months ago
  
  If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
  For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
  For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
  For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
  
  Helpful?
Anonymous

11 months ago

How is shipping temperature determined? And how is it related to the product storage temperature?

1 answer
1. Technical Support
  
  11 months ago
  
  Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
  
  Helpful?
a year ago

What is the active fraction of Imipenem - Pharmaceutical Secondary Standard; Certified Reference Material?

1 answer
1. Technical Support
  
  a year ago
  
  The mass fraction percentage purity is reported for this product in the lot-specific Certificate of Analysis. It is not assessed for biological activity during the quality control process, however.
  
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