PHR1841

Amoxapine

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(s): Amoxapine, 2-Chloro-11-(1-piperazinyl)dibenz[b,f][1,4]oxazepine
• Empirical Formula (Hill Notation): C₁₇H₁₆ClN₃O
• CAS Number: 14028-44-5
• Molecular Weight: 313.78
• EC Number: 237-867-1
• MDL number: MFCD00069210
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material; pharmaceutical secondary standard
• Quality Level: 300
• agency: traceable to USP 1031401
• API family: amoxapine
• CofA: current certificate can be downloaded
• packaging: pkg of 500 mg
• application(s): pharmaceutical
• format: neat
• storage temp.: 2-30°C
• SMILES string: Clc1ccc2Oc3ccccc3N=C(N4CCNCC4)c2c1
• InChI: 1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2
• InChI key: QWGDMFLQWFTERH-UHFFFAOYSA-N
• Gene Information: human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), SLC6A2(6530), SLC6A4(6532)

Description

General description

Amoxapine is a tricyclic antidepressant known to inhibit reuptake of neuronal transmitter. The drug helps in controlling agitation and anxiety along with depression.[1][2]
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Application

Amoxapine may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by ultraviolet-spectrophotometric method.[2]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

To see an example of a Certificate of Analysis for this material enter LRAB2753 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable