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PHR1909

Supelco

Atenolol

Pharmaceutical Secondary Standard; Certified Reference Material

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Synonym(s):
Atenolol, (±)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide, 4-[2′-Hydroxy-3′-(isopropylamino)propoxy]phenylacetamide
Empirical Formula (Hill Notation):
C14H22N2O3
CAS Number:
Molecular Weight:
266.34
EC Number:
MDL number:
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to BP 492
traceable to Ph. Eur. A1340000
traceable to USP 1044403

API family

atenolol

form

powder

CofA

current certificate can be downloaded

packaging

pkg of 500 mg

application(s)

pharmaceutical

storage temp.

2-30°C

SMILES string

CC(C)NCC(O)COc1ccc(CC(N)=O)cc1

InChI

1S/C14H22N2O3/c1-10(2)16-8-12(17)9-19-13-5-3-11(4-6-13)7-14(15)18/h3-6,10,12,16-17H,7-9H2,1-2H3,(H2,15,18)

InChI key

METKIMKYRPQLGS-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153)

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This Item
A1340000A76551044403
Atenolol Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1909

Atenolol

Atenolol European Pharmacopoeia (EP) Reference Standard

A1340000

Atenolol

Atenolol ≥98% (TLC), powder

Sigma-Aldrich

A7655

Atenolol

Atenolol United States Pharmacopeia (USP) Reference Standard

USP

1044403

Atenolol

form

powder

form

-

form

powder

form

-

packaging

pkg of 500 mg

packaging

-

packaging

-

packaging

-

application(s)

pharmaceutical

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

pharmaceutical (small molecule)

storage temp.

2-30°C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

Quality Level

300

Quality Level

-

Quality Level

-

Quality Level

-

General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Atenolol is a beta-1 blocker used in the treatment of various cardiovascular diseases.

Application

This pharmaceutical secondary standard can also be used as follows:

  • Simultaneous analysis of atenolol and nifedipine using magnesium oxide-nanoplatelets (MgO-NPLs) modified screen-printed electrodes (SPEs) by differential pulse voltammetry (DPV) from pharmaceutical dosage forms and urine samples
  • Voltammetric determination of amlodipine besylate and atenolol in their combined pharmaceutical formulations using a cathodically pretreated-boron doped diamond electrode (CP-BDDE)
  • Spectrofluorimetric determination of atenolol using gold nanoparticles (AuNPs) based photo probes in commercial tablets
  • Amperometric estimation of atenolol using bismuth vanadate-bismuth(III) oxide (BiVO4–Bi2O) composite electrode in pharmaceutical formulations and human urine samples
  • Development of a reversed phase-high performance liquid chromatography (RP-HPLC) method coupled to a photodiode array detector (PDA) for the quantitative analysis of atenolol and trimetazidine in human urine and pharmaceutical tablets

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0712 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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T1503
Product Number
-
25G
Pack Size/Quantity

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705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

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BiVO4-Bi2O3/ITO electrodes prepared by layer-by-layer: application in the determination of atenolol in pharmaceutical formulations and urine
Afonso R, et al.
Journal of Electroanalytical Chemistry, 765, 30-36 (2016)
Simultaneous voltammetric determination of antihypertensive drugs nifedipine and atenolol utilizing MgO nanoplatelet modified screen-printed electrodes in pharmaceuticals and human fluids
Khairy M, et al.
Sensors and Actuators B, Chemical, 252, 1045-1054 (2017)
Simultaneous voltammetric determination of antihypertensive drugs amlodipine and atenolol in pharmaceuticals using a cathodically pretreated boron-doped diamond electrode
Moraes JT, et al.
Journal of the Brazilian Chemical Society, 27, 1264-1272 (2016)

Articles

TLC plates, with silica gel, gypsum as binder, International Pharmacopoeia compliant, for identification of Atenolol and Chlorthalidone in tablets.

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