PMC1102

Acetonitrile

≥99.75%, ISOM8^™, anhydrous

• Synonym(s): ACN, Acetonitrile, MeCN, Cyanomethane
• Linear Formula: CH₃CN
• CAS Number: 75-05-8
• Molecular Weight: 41.05
• UNSPSC Code: 12352148
• Beilstein/REAXYS Number: 741857
• MDL number: MFCD00001878
• Assay: ≥99.75%
• Grade: anhydrous
• Bp: 81-82 °C (lit.), 82 °C ((lit))
• Vapor pressure: 44 mmHg ( 20 °C), 72.8 mmHg ( 20 °C)

Properties

• Quality Segment: 300
• grade: anhydrous
• vapor density: 1.41 (vs air), 1.59 (vs air)
• vapor pressure: 44 mmHg ( 20 °C), 72.8 mmHg ( 20 °C)
• description: Various Returnable Container Options
• product line: ISOM8^™
• assay: ≥99.75%
• form: liquid
• autoignition temp.: 523 °C (975°F), 973 °F
• shelf life: 36 mo.
• expl. lim.: 16 %
• packaging: Sure/Seal^™ of 100 mL, Sure/Seal^™ of 12 × 100 mL, Sure/Seal^™ of 2 L, Sure/Seal^™ of 4 × 2 L
• impurities: <0.001% water (<0.005% water for individual packaging amounts less than 500 mL)
• evapn. residue: <0.0005%
• refractive index: n/D 1.3440 (lit.), n20/D 1.344 (lit.)
• pH: (10 ppmacidity (format:neat))
• bp: 81-82 °C (lit.), 82 °C ((lit))
• mp: -45 °C, −45 °C (lit.)
• transition temp: flash point 6 °C (42°F)
• solubility: miscible
• density: 0.786 g/mL at 25 °C
• cation traces: (See Dossier)
• application(s): diagnostic assay manufacturing; life science and biopharma
• SMILES string: CC#N
• InChI: 1S/C2H3N/c1-2-3/h1H3
• InChI key: WEVYAHXRMPXWCK-UHFFFAOYSA-N

Description

General description

Welcome to our ISOM8^™ line of high-quality products available and able to scale for manufacturing. Within our ISOM8 team, we have expertise and documentation to support ISO 9001 industrial and non-GMP pharma production needs, as defined by our M-Clarity^™ Program.

Our portfolio of ISOM8 products and chemistries is ever evolving to support our valued Sigma-Aldrich^® customers′ requirements. Please navigate to our documents section to look at dossiers and other quality documentation for this product, provided with support of our Elevated Assurance Program.

Our ISOM8^™ Acetonitrile is available within the USA with our ReCycler^® Solvent System for returnable, reusable, and readily available bulk solvent delivery, to reduce packaging waste and help you achieve your sustainablility goals. To request ISOM8 and other product lines in returnable containers Click Here.

Unlock your manufacturing potential with our comprehensive program. By choosing ISOM8^™ chemicals, ensure compliance while fostering innovation and excellence. Connect with us to learn more about how we can support your journey toward manufacturing success.

Application

Organic Synthesis
Acetonitrile plays a crucial role in various organic reactions, including nucleophilic substitutions and coupling reactions, facilitating the formation of complex molecules.
Extraction Processes
This solvent is effective for extracting active ingredients and impurities from raw materials, enhancing the efficiency of purification processes in both industrial and non-GMP pharmaceutical settings.

Features and Benefits

FEATURES

• Anhydrous Solvent: The absence of water ensures that it is ideal for reactions and processes that require moisture-free conditions.
  
• High Purity: We ensure that our anhydrous acetonitrile meets stringent quality standards, making it suitable for a wide range of demanding applications.
• Versatile Applications: Acetonitrile is a polar aprotic solvent, which makes it effective for a wide range of chemical reactions, including nucleophilic substitutions and extractions.
  
• Returnable Containers: Our anhydrous acetonitrile is offered in returnable containers, designed for industry to minimize waste, and support sustainable practices.

BENEFITS

• Improved Reaction Efficiency: The anhydrous nature reduces side reactions that can occur in the presence of water, possibly improving yields in select chemical syntheses.
• Cost Efficiency: Comparably lower-cost, non-GMP product production combined with returnable containers can lead to significant cost savings over time.
• Convenience: The returnable container system simplifies logistics to manage inventory and replenishment without the need for additional waste disposal.

Packaging

100mL to 2L bottles are packaged in Sure/Seal^™containers.

For bulk amounts in US, we offer returnables through ReCycler^® Program.

Legal Information

ISOM8 is a trademark of Sigma-Aldrich Co. LLC

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

M-CLARITY is a trademark of Merck KGaA, Darmstadt, Germany

RECYCLER is a registered trademark of Merck KGaA, Darmstadt, Germany

SIGMA-ALDRICH is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Codes: H225,H302 + H312 + H332,H319
• Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Storage Class: 3 - Flammable liquids
• Flash Point (°F): 35.6 °F - closed cup
• Flash Point (°C): 2.0 °C - closed cup