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Key Documents

SMB01363

Sigma-Aldrich

5α-Tetrahydrocortisol

≥95% (HPLC)

Synonym(s):

5α-Pregnane-3α,11β,17α,21-tetrol-20-one, α-THF, 5 alpha-Tetrahydrocortisol, ATHF, Allo-3a-tetrahydrocortisol, 3α,11β,17α,21-Tetrahydroxy-5α-pregnan-20-one, 3α,5α-Tetrahydrocortisol, Allopregnane-3α,11β,17α,21-tetrol-20-one, Allotetrahydrocortisol, Kendall’s compound C, Reichstein’s substance C

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About This Item

Empirical Formula (Hill Notation):
C21H34O5
CAS Number:
Molecular Weight:
366.49
MDL number:
UNSPSC Code:
51111800
NACRES:
NA.21

Quality Level

assay

≥95% (HPLC)

form

solid

composition

(3α,5α)-3,11,17,21-Tetrahydroxypregnan-20-one, ≤100%

packaging

pkg of 25 mg
pkg of 5 mg

color

white to beige

mp

244.5  °C

density

1.205 g/cm3

storage temp.

2-8°C

SMILES string

C[C@@]12CC[C@H](O)C[C@H]1CC[C@@H]3[C@H]4CC[C@@](O)(C(=O)CO)[C@@]4(C)C[C@@H](O)[C@@H]23

InChI

1S/C21H34O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-16,18,22-24,26H,3-11H2,1-2H3/t12-,13+,14-,15-,16-,18+,19-,20-,21-/m0/s1

InChI key

AODPIQQILQLWGS-FDSHTENPSA-N

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General description

5α-Tetrahydrocortisol, also known as Allo-3a-tetrahydro cortisol (ATHC), a synthetic corticosteroid hormone derived from cortisol, is widely employed in biochemical and proteomics research. It is a metabolite of cortisol, a natural glucocorticoid that is used to treat various immune, inflammatory, and neoplastic conditions. In the context of medical diagnosis, a higher ratio of specific urinary metabolites can indicate the presence of Apparent Mineralocorticoid Excess (AME) syndrome, a rare form of hypertension linked to abnormalities in cortisol metabolism.

Application

5α-Tetrahydrocortisol finds application as a Biomarker in AME studies pertaining to Cortisol metabolism research

Features and Benefits

  • Can be used in Metabolomics and Biochemical research
  • High-quality compound suitable for multiple research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Aquatic Chronic 4 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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