T1600000

α-Tocopherol acetate

Name: α-Tocopherol acetate
Brand: SIAL
Price: 203.2 USD

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

DL-α-Tocopherol acetate, Vitamin E acetate, all-rac-α-Tocopheryl acetate

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About This Item

Empirical Formula (Hill Notation):

C₃₁H₅₂O₃

CAS Number:

7695-91-2

Molecular Weight:

472.74

Beilstein/REAXYS Number:

97512

EC Number:

231-710-0

MDL number:

MFCD00072042

UNSPSC Code:

41116107

PubChem Substance ID:

329826681

NACRES:

NA.24

Key Documents

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biological source

synthetic

grade

pharmaceutical primary standard

agency

API family

tocopherol

form

liquid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

density

0.96 g/mL at 20 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

InChI key

ZAKOWWREFLAJOT-CEFNRUSXSA-N

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Show Differences

1 of 4

This Item	1667701	Y0000384	92359
T1600000 α-Tocopherol acetate	USP 1667701 Alpha Tocopheryl Acetate	Y0000384 All-rac-alpha-tocopheryl acetate for peak identification	Supelco 92359 DL-α-Tocopherol acetate
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) vitamins, nutraceuticals, and natural products
technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) -	technique(s) gas chromatography (GC): suitable, liquid chromatography (LC): suitable	technique(s) gas chromatography (GC): suitable
form liquid	form -	form solid	form viscous liquid
format neat	format neat	format neat	format neat
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade certified reference material, TraceCERT^®
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia. α-Tocopherol acetate, a supplement of α-tocopherol, is an active form of vitamin E. This lipid-soluble antioxidant is found in whole grains, nuts, and oils. It is known to scavenge reactive oxygen species by interacting with lipids during oxidative stress.[1][2][3]

Application

α-Tocopherol acetate may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.[4][5]

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

No data available

flash_point_c

No data available

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RRR-?-Tocopheryl acetate

European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare

European pharmacopoeia, 3804-3805 (2013)

ANTIOXIDANTS-Role of Antioxidant Nutrients in Defense Systems

Encyclopedia of food sciences and nutrition, 282-289 (2003)

Determination of eight water-and fat-soluble vitamins in multi-vitamin pharmaceutical formulations by high-performance liquid chromatography

Moreno P and Salvado V

Journal of Chromatography A, 870(1-2), 207-215 (2000)

Flow injection spectrophotometric determination of vitamin E in pharmaceuticals, milk powder and blood serum using potassium ferricyanide-Fe (III) detection system

Jadoon S, et al.

Chinese Chemical Letters = Zhongguo Hua Xue Kuai Bao, 21(6), 712-715 (2010)

Vitamin E facilitates the inactivation of the kinase Akt by the phosphatase PHLPP1.

Po-Hsien Huang et al.

Science signaling, 6(267), ra19-ra19 (2013-03-21)

Vitamin E is a fat-soluble vitamin with antioxidant properties. Tocopherols are the predominant form of vitamin E found in the diet and in supplements and have garnered interest for their potential cancer therapeutic and preventive effects, such as the dephosphorylation

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