Borong Zhou et al.
Nature microbiology, 5(12), 1576-1587 (2020-10-21)
Sepsis is the most common cause of death for patients in intensive care worldwide due to a dysregulated host response to infection. Here, we investigate the role of sequestosome-1 (SQSTM1/p62), an autophagy receptor that functions as a regulator of innate...
Artesunate protects immunosuppression mice induced by glucocorticoids via enhancing pro-inflammatory cytokines release and bacterial clearance.
Wang, et al.
European Journal of Pharmacology, 890, 173630-173630 (2021)
David Frommhold et al.
The Journal of experimental medicine, 205(6), 1435-1446 (2008-06-04)
Recent in vitro studies have suggested a role for sialylation in chemokine receptor binding to its ligand (Bannert, N., S. Craig, M. Farzan, D. Sogah, N.V. Santo, H. Choe, and J. Sodroski. 2001. J. Exp. Med. 194:1661-1673). This prompted us...
Xiaojiao Wang et al.
Signal transduction and targeted therapy, 5(1), 35-35 (2020-04-17)
The inhibitory receptor signal regulatory protein-α (Sirpα) is a myeloid-specific immune checkpoint that engages the "don't eat me" signal CD47, which is expressed on tumor and normal tissue cells. However, the profile and regulatory mechanism of Sirpα expression in tumor-associated...
Matthew C Hyman et al.
The Journal of clinical investigation, 119(5), 1136-1149 (2009-04-22)
Leukocyte and platelet accumulation at sites of cerebral ischemia exacerbate cerebral damage. The ectoenzyme CD39 on the plasmalemma of endothelial cells metabolizes ADP to suppress platelet accumulation in the ischemic brain. However, the role of leukocyte surface CD39 in regulating...