T9159

Sigma-Aldrich

Trichloroacetic acid

BioXtra, ≥99.0%

Synonym(s):
TCA
Linear Formula:
Cl3CCOOH
CAS Number:
Molecular Weight:
163.39
Beilstein/REAXYS Number:
970119
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NB.22

Quality Level

vapor density

<1 (vs air)

vapor pressure

1 mmHg ( 51 °C)

product line

BioXtra

assay

≥99.0%

impurities

≤0.0005% Phosphorus (P)
≤0.1% Insoluble matter

ign. residue

≤0.03%

refractive index

n20/D 1.62 (lit.)

bp

196 °C (lit.)

mp

54-58 °C (lit.)

solubility

H2O: 0.5 M at 20 °C, clear, colorless

density

1.62 g/mL at 25 °C (lit.)

anion traces

sulfate (SO42-): ≤0.05%

cation traces

Al: ≤0.0005%
Ca: ≤0.005%
Cu: ≤0.0005%
Fe: ≤0.001%
K: ≤0.01%
Mg: ≤0.0005%
NH4+: ≤0.05%
Na: ≤0.005%
Pb: ≤0.001%
Zn: ≤0.0005%

storage temp.

2-8°C

SMILES string

OC(=O)C(Cl)(Cl)Cl

InChI

1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)

InChI key

YNJBWRMUSHSURL-UHFFFAOYSA-N

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General description

Trichloroacetic acid (TCA) is an important metabolic product of trichloroethylene (TCE) metabolism.

Application

Trichloroacetic acid has been used:
  • for protein precipitation
  • as a component in the extract solution used for the measurement of malondialdehyde and glutathione
  • to precipitate the transfected and treated cells in [3H]-thymidine incorporation assay

Traditionally used to precipitate protein. Has been used to determine protein concentration by quantitative precipitation. Used as decalcifier and fixative in microscopy.

Packaging

100, 250, 500 g in glass bottle

Biochem/physiol Actions

TCA might act as a carcinogen, targeting liver. It might be used as an acid decalcifying agent. TCA helps in nuclear staining.

Signal Word

Danger

Hazard Statements

hazcat

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A - STOT SE 3

Target Organs

Respiratory system

storage_class_code

8B - Non-combustible, corrosive hazardous materials

WGK Germany

WGK 2

Flash Point(F)

235.4 °F - closed cup

Flash Point(C)

> 113 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

Rapid analysis of total plasma homocysteine by tandem mass spectrometry
Tuschl K, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 351(1-2), 139-141 (2005)
Analysis of malondialdehyde, chlorophyll proline, soluble sugar, and glutathione content in Arabidopsis seedling
Zhang Z and Huang R
Bio-protocol, 3, e817-e817 (2013)
Histophatologic Techniques (2006)
Circulating fibrocytes stabilize blood vessels during angiogenesis in a paracrine manner
Li J, et al.
The American Journal of Pathology, 184(2), 556-571 (2014)
Bo Chen et al.
Translational stroke research, 10(1), 91-103 (2018-03-24)
The transient receptor potential melastatin 4 (TRPM4) channel has been suggested to play a key role in the treatment of ischemic stroke. However, in vivo evaluation of TRPM4 channel, in particular by direct channel suppression, is lacking. In this study...

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