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V0300000

Vinblastine sulfate

European Pharmacopoeia (EP) Reference Standard

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Synonym(s):
Vinblastine sulfate salt, VLB, Vincaleukoblastine sulfate salt
Empirical Formula (Hill Notation):
C46H58N4O9 · H2SO4
CAS Number:
Molecular Weight:
909.05
Beilstein/REAXYS Number:
3659812
MDL number:
PubChem Substance ID:
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

vinblastine

manufacturer/tradename

EDQM

mp

267 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−70°C

SMILES string

OS(O)(=O)=O.[H][C@@]12CN(CCc3c([nH]c4ccccc34)[C@@](C1)(C(=O)OC)c5cc6c(cc5OC)N(C)[C@@]7([H])[C@](O)([C@H](OC(C)=O)[C@]8(CC)C=CCN9CC[C@]67[C@]89[H])C(=O)OC)C[C@](O)(CC)C2

InChI

1S/C46H58N4O9.H2O4S/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7;1-5(2,3)4/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3;(H2,1,2,3,4)/t28-,37-,38+,39+,42-,43+,44+,45-,46-;/m0./s1

InChI key

KDQAABAKXDWYSZ-PNYVAJAMSA-N

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1 of 4

This Item
1713004677175-MV0400000
Vinblastine sulfate European Pharmacopoeia (EP) Reference Standard

V0300000

Vinblastine sulfate

Vinblastine sulfate United States Pharmacopeia (USP) Reference Standard

1713004

Vinblastine sulfate

Vinblastine Sulfate Antitumor alkaloid drug.

677175-M

Vinblastine Sulfate

Vincristine sulfate European Pharmacopoeia (EP) Reference Standard

V0400000

Vincristine sulfate

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

-

grade

pharmaceutical primary standard

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

-

format

neat

API family

vinblastine

API family

vinblastine

API family

-

API family

vincristine

mp

267 °C (dec.) (lit.)

mp

267 °C (dec.) (lit.)

mp

-

mp

-

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Vinblastine sulfate EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

Exclamation markHealth hazard

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Muta. 2 - Repr. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3


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Mizuki Kuboki et al.
Biochemical and biophysical research communications, 456(3), 810-814 (2014-12-17)
DTCM-glutarimide (DTCM-G) is a newly found anti-inflammatory agent. In the course of experiments with lymphoma cells, we found that DTCM-G induced specific RelB cleavage. Anticancer agent vinblastine also induced the specific RelB cleavage in human fibrosarcoma HT1080 cells. The site-directed
Victor S Goldmacher et al.
PloS one, 10(2), e0117523-e0117523 (2015-02-12)
The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their association with tubulin or microtubules. To identify the mechanisms of this intracellular accumulation and exceptional cytotoxicity of maytansinoids we

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