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Y0000095

Diosmin for system suitability

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Diosmin, 3′,5,7-Trihydroxy-4′-methoxyflavone 7-rutinoside, Barosmin, Buchu resin, Diosmetin 7-O-rhamnosylglucoside, Diosmetin 7-rutinoside

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15 MG

$167.00

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About This Item

Empirical Formula (Hill Notation):
C28H32O15
CAS Number:
520-27-4
Molecular Weight:
608.54
NACRES:
NA.24
PubChem Substance ID:
329830840
UNSPSC Code:
41116107
MDL number:
MFCD00009772

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Product Name

Diosmin for system suitability, European Pharmacopoeia (EP) Reference Standard

InChI

1S/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1

SMILES string

COc1ccc(cc1O)C2=CC(=O)c3c(O)cc(O[C@@H]4O[C@H](CO[C@@H]5O[C@@H](C)[C@H](O)[C@@H](O)[C@H]5O)[C@@H](O)[C@H](O)[C@H]4O)cc3O2

InChI key

GZSOSUNBTXMUFQ-YFAPSIMESA-N

grade

pharmaceutical primary standard

API family

diosmin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

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Show Differences

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This Item
1213318PHR2799PHL82527
Diosmin for system suitability European Pharmacopoeia (EP) Reference Standard

Y0000095

Diosmin for system suitability

Diosmin United States Pharmacopeia (USP) Reference Standard

USP

1213318

Diosmin

Diosmin certified reference material, pharmaceutical secondary standard

Supelco

PHR2799

Diosmin

Diosmin phyproof® Reference Substance

PHL82527

Diosmin

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

certified reference material, pharmaceutical secondary standard

grade

primary reference standard

manufacturer/tradename

EDQM

manufacturer/tradename

USP

manufacturer/tradename

-

manufacturer/tradename

PhytoLab

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical

application(s)

-

format

neat

format

neat

format

-

format

-

API family

diosmin

API family

diosmin

API family

diosmin

API family

-

storage temp.

2-8°C

storage temp.

-

storage temp.

2-30°C

storage temp.

-

Application

Diosmin for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Citrus flavonoid. Modification of hesperidin. Studied for its chemopreventive properties, including anti-proliferative and anti-inflammatory.

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Other Notes

Sales restrictions may apply.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Anna Bogucka-Kocka et al.
Natural product communications, 8(4), 545-550 (2013-06-07)
Diosmin is a naturally occurring flavone glycoside used in the treatment of venous diseases. In this review, we present the clinical aspects of the use of diosmin preparations in venous stasis, hemorrheologic disorders and vein wall remodeling. Because of its
Petr Vrbata et al.
International journal of pharmaceutics, 473(1-2), 407-413 (2014-07-30)
A nanofibrous membrane carrier for nearly water insoluble drug diosmin was formulated. The aim of this study was to evaluate the drug release and dissolution properties in an aqueous buffer of pH 7.8, and to compare the suitability of the
Monograph. Diosmin.
Alternative medicine review : a journal of clinical therapeutic, 9(3), 308-311 (2004-09-25)
[Hemorrhoids and conservative treatment. Review of the literature on the use of diosmin and micronized hesperidin].
F La Torre et al.
Minerva chirurgica, 54(12), 909-916 (2000-03-29)
Prasad Neerati et al.
Pharmacological reports : PR, 67(2), 339-344 (2015-02-26)
Diosmin is a natural flavone glycoside, a potent P-glycoprotein (P-gp) inhibitor in cultured cells and have the potential to alter the bioavailability of P-gp substrate drugs. However, the interaction between diosmin and fexofenadine is unreported. Hence, the present study was
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