Y0000467

Thiamine hydrochloride

Name: Thiamine hydrochloride
Brand: SIAL
Price: 192.8 USD
Availability: InStock

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Aneurine hydrochloride, Vitamin B₁ hydrochloride

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10 MG

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₇ClN₄OS · HCl

CAS Number:

67-03-8

Molecular Weight:

337.27

Beilstein/REAXYS Number:

3851771

MDL number:

MFCD00012780

UNSPSC Code:

41116107

PubChem Substance ID:

329830973

NACRES:

NA.24

Key Documents

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grade

pharmaceutical primary standard

API family

thiamine

manufacturer/tradename

EDQM

mp

250 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]

InChI

1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1

InChI key

DPJRMOMPQZCRJU-UHFFFAOYSA-M

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Show Differences

1 of 4

This Item	PHR1037	47858	T4562
Y0000467 Thiamine hydrochloride	Supelco PHR1037 Thiamine hydrochloride	Supelco 47858 Thiamine Hydrochloride (B1)	Sigma-Aldrich T4562 Thiamine hydrochloride
grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard	grade analytical standard	grade -
manufacturer/tradename EDQM	manufacturer/tradename -	manufacturer/tradename -	manufacturer/tradename -
format neat	format neat	format neat	format -
application(s) pharmaceutical (small molecule)	application(s) food and beverages	application(s) pharmaceutical (small molecule) vitamins, nutraceuticals, and natural products	application(s) pharmaceutical (small molecule)
API family thiamine	API family thiamine	API family -	API family -
mp 250 °C (dec.) (lit.)	mp 250 °C (dec.) (lit.)	mp 250 °C (dec.) (lit.)	mp 250 °C (dec.) (lit.)

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing pharmacopoeia.

Thiamine hydrochloride is a water soluble vitamin, which belongs to the B-complex group of vitamins. It can exist both as a hemihydrate and as a nonstoichiometric hydrate. It can generally act like a co-enzyme for biochemical reactions involved in carbohydrate metabolism.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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High-performance liquid chromatography method for the simultaneous determination of thiamine hydrochloride, pyridoxine hydrochloride and cyanocobalamin in pharmaceutical formulations using coulometric electrochemical and ultraviolet detection

Marszall LM, et al.

Journal of Chromatography A, 1094(1-2), 91-98 (2005)

Pyrroloquinoline quinone-secreting probiotic Escherichia coli Nissle 1917 ameliorates ethanol-induced oxidative damage and hyperlipidemia in rats.

Ashish K Singh et al.

Alcoholism, clinical and experimental research, 38(7), 2127-2137 (2014-06-17)

Chronic ethanol (EtOH) consumption is associated with oxidative tissue damage, decrease in antioxidant enzyme activities, and increase in hepatic and plasma lipids. This study investigates the effect of modified probiotic Escherichia coli Nissle 1917 (EcN) secreting pyrroloquinoline quinone (PQQ) against

Determination of four forms of vitamin B12 and other B vitamins in seawater by liquid chromatography/tandem mass spectrometry.

Katherine R Heal et al.

Rapid communications in mass spectrometry : RCM, 28(22), 2398-2404 (2014-10-11)

Vitamin B(12) is an essential nutrient for more than half of surveyed marine algae species, but methods for directly measuring this important cofactor in seawater are limited. Current mass spectrometry methods do not quantify all forms of B(12), potentially missing

The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy.

Qiang Zhang et al.

Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1656-1662 (2014-07-27)

The clinical development of fedratinib, a Janus kinase (JAK2) inhibitor, was terminated after reports of Wernicke's encephalopathy in myelofibrosis patients. Since Wernicke's encephalopathy is induced by thiamine deficiency, investigations were conducted to probe possible mechanisms through which fedratinib may lead

Prion protein-coated magnetic beads: synthesis, characterization and development of a new ligands screening method.

Marcela Cristina de Moraes et al.

Journal of chromatography. A, 1379, 1-8 (2015-01-13)

Prion diseases are characterized by protein aggregation and neurodegeneration. Conversion of the native prion protein (PrP(C)) into the abnormal scrapie PrP isoform (PrP(Sc)), which undergoes aggregation and can eventually form amyloid fibrils, is a critical step leading to the characteristic

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