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Y0000471

Buspirone for system suitability

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Buspirone hydrochloride, N-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride

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2 MG

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About This Item

Empirical Formula (Hill Notation):
C21H31N5O2 · HCl
CAS Number:
33386-08-2
Molecular Weight:
421.96
MDL number:
MFCD00078569
UNSPSC Code:
41116107
PubChem Substance ID:
329830975
NACRES:
NA.24

Key Documents

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grade

pharmaceutical primary standard

API family

buspirone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

Cl[H].O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4ncccn4

InChI

1S/C21H31N5O2.ClH/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20;/h5,8-9H,1-4,6-7,10-17H2;1H

InChI key

RICLFGYGYQXUFH-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350)

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1 of 4

This Item
Y00001311078802Y0000851
Buspirone for system suitability European Pharmacopoeia (EP) Reference Standard

Y0000471

Buspirone for system suitability

Buspirone hydrochloride European Pharmacopoeia (EP) Reference Standard

Y0000131

Buspirone hydrochloride

Buspirone hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1078802

Buspirone hydrochloride

Doxepin for system suitability European Pharmacopoeia (EP) Reference Standard

Y0000851

Doxepin for system suitability

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

manufacturer/tradename

USP

manufacturer/tradename

EDQM

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

grade

pharmaceutical primary standard

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

format

neat

format

neat

format

neat

format

neat

API family

buspirone

API family

buspirone

API family

buspirone

API family

doxepin

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Buspirone for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

5-HT1A serotonin receptor agonist; anxiolytic.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

comparable product

Product No.
Description
Pricing

related product

Product No.
Description
Pricing

1078573

Buspirone Related Compound A, United States Pharmacopeia (USP) Reference Standard

1078824

Buspirone Related Compound L, United States Pharmacopeia (USP) Reference Standard

1078835

Buspirone Related Compound N, United States Pharmacopeia (USP) Reference Standard

1078813

Buspirone Related Compound G, United States Pharmacopeia (USP) Reference Standard

1078642

Buspirone Related Compound K, United States Pharmacopeia (USP) Reference Standard

PHR2845

Buspirone Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2846

Buspirone Related Compound G, certified reference material, pharmaceutical secondary standard

PHR2847

Buspirone Related Compound K, pharmaceutical secondary standard, certified reference material

PHR2848

Buspirone Related Compound N

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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M W Moore et al.
Respiratory physiology & neurobiology, 183(1), 35-40 (2012-05-19)
The purpose was to determine if 2 weeks of buspirone suppressed post-hypoxic breathing instability and pauses in the C57BL/6J (B6) mouse. Study groups were vehicle (saline, n=8), low-dose (1.5 mg/kg, n=8), and high-dose buspirone (5.0 mg/kg, n=8). Frequency, measured by
Maurizio Fava et al.
Journal of psychiatric research, 46(12), 1553-1563 (2012-09-25)
We used in vitro neurogenesis-based human neural stem cell (hNSCs) assays and rodent in vivo behavioral assays to identify potential novel antidepressants. A combination of buspirone and melatonin displayed antidepressant activity in these assays whereas neither buspirone nor melatonin alone
Karl Strecker et al.
Journal of neural transmission (Vienna, Austria : 1996), 119(11), 1351-1359 (2012-05-10)
Drug-induced dyskinesia is a major complication of dopamine replacement therapy in advanced Parkinson's disease consisting of dystonia, chorea and athetosis. Agonists at 5-HT1A-receptors attenuate levodopa-induced motor complications in non-human primates. Mice with increased dopamine D2 receptor (DRD2) signalling due to
Nupur Nag et al.
Cerebellum (London, England), 12(1), 74-82 (2012-06-22)
Spinocerebellar ataxias are autosomal dominant diseases, associated in some types with a CAG repeat expansion, and characterised by a progressive loss of motor function. Currently, as there is no cure for most ataxias, treatment predominantly involves physical therapy. Various symptomatic
Shujun Zhou et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 903, 75-80 (2012-07-27)
Chinensinaphthol methyl ether (CME) is a potential pharmacologically active ingredient isolated from the dried plants of Justicia procumbens L. (Acanthaceae). A sensitive and specific LC-MS/MS method was developed and validated for the analysis of CME in rat plasma using buspirone
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