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Y0000757

Riboflavin for peak identification

European Pharmacopoeia (EP) Reference Standard

Synonym(s):
(−)-Riboflavin, Lactoflavin, Vitamin B2, Vitamin G
Empirical Formula (Hill Notation):
C17H20N4O6
CAS Number:
Molecular Weight:
376.36
Beilstein:
97825
MDL number:
PubChem Substance ID:
NACRES:
NA.24

biological source

synthetic

grade

pharmaceutical primary standard

Agency

EP

API family

riboflavin

form

solid

manufacturer/tradename

EDQM

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

mp

290 °C (dec.) (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC1=C(C)C=C(N(C[C@H](O)[C@@H]([C@H](O)CO)O)C(C2=N3)=NC(NC2=O)=O)C3=C1

InChI

1S/C17H20N4O6/c1-7-3-9-10(4-8(7)2)21(5-11(23)14(25)12(24)6-22)15-13(18-9)16(26)20-17(27)19-15/h3-4,11-12,14,22-25H,5-6H2,1-2H3,(H,20,26,27)/t11-,12+,14-/m0/s1

InChI key

AUNGANRZJHBGPY-SCRDCRAPSA-N

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1 of 4

This Item
R0600000160300647861
Riboflavin European Pharmacopoeia (EP) Reference Standard

R0600000

Riboflavin

Riboflavin United States Pharmacopeia (USP) Reference Standard

USP

1603006

Riboflavin

Riboflavin (B2) analytical standard

Supelco

47861

Riboflavin (B2)

form

solid

form

solid

form

-

form

solid

manufacturer/tradename

EDQM

manufacturer/tradename

EDQM

manufacturer/tradename

USP

manufacturer/tradename

-

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

gas chromatography (GC): suitable, liquid chromatography (LC): suitable

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

pharmaceutical (small molecule)

application(s)

food and beverages

format

neat

format

neat

format

neat

format

neat

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Riboflavin, also known as vitamin B2, is crucial for human nutrition, and growth. It finds potential applications in biological redox reactions and is found in several foodstuffs, energy drinks, and vitamin formulations.

Application

Riboflavin may be used as an EP reference standard for the determination of the analyte in pharmaceutical formulations by liquid chromatography.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1


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Riboflavin
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 5(2), 3484-3485 (2008)
Differential pulse polarographic method development and validation of riboflavin in pharmaceutical formulation
Kashid LM and Patil SV
International Journal of Scientific Research, 5(2), 325-334 (2015)
Simultaneous determination of riboflavin phosphate and other ingredients in a multivitamin pharmaceutical preparation by on-line automated LC coupled with pre-column immobilized enzyme reactor
Ono M, et al.
Journal of Pharmaceutical and Biomedical Analysis, 29(1-2), 325-334 (2002)
Olivier Richoz et al.
Investigative ophthalmology & visual science, 55(9), 5783-5787 (2014-07-24)
When treating peripheral ectatic disease-like pellucid marginal degeneration (PMD), corneal cross-linking with UV-A and riboflavin (CXL) must be applied eccentrically to the periphery of the lower cornea, partly irradiating the corneal limbus. Here, we investigated the effect of standard and
Bárbara J Henriques et al.
Current medicinal chemistry, 17(32), 3842-3854 (2010-09-23)
Riboflavin, commonly known as vitamin B2, is the precursor of flavin cofactors. It is present in our typical diet, and inside the cells it is metabolized to FMN and FAD. As a result of their rather unique and flexible chemical

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