Y0000810

Acemetacin

European Pharmacopoeia (EP) Reference Standard

• Synonym(s): 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid carboxymethyl ester
• Empirical Formula (Hill Notation): C₂₁H₁₈ClNO₆
• CAS Number: 53164-05-9
• Molecular Weight: 415.82
• MDL number: MFCD00151473
• UNSPSC Code: 41116107
• PubChem Substance ID: 329831163
• NACRES: NA.24

Properties

• grade: pharmaceutical primary standard
• API family: acemetacin
• manufacturer/tradename: EDQM
• application(s): pharmaceutical (small molecule)
• format: neat
• storage temp.: 2-8°C
• SMILES string: COc1ccc2n(c(C)c(CC(=O)OCC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3
• InChI: 1S/C21H18ClNO6/c1-12-16(10-20(26)29-11-19(24)25)17-9-15(28-2)7-8-18(17)23(12)21(27)13-3-5-14(22)6-4-13/h3-9H,10-11H2,1-2H3,(H,24,25)
• InChI key: FSQKKOOTNAMONP-UHFFFAOYSA-N
• Gene Information: human ... PTGS1(5742), PTGS2(5743)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Acemetacin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

An NSAID that specifically potentiates the cytoxicity of anthracyclines (doxorubicin, daunorubicin and epirubium). Circumvents MRP-mediated multidrug resistance.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Safety Information

• pictograms: GHS06
• signalword: Danger
• hcodes: H300 + H310 + H330
• pcodes: P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310
• Hazard Classifications: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3