Hydrastine hydrochloride

European Pharmacopoeia (EP) Reference Standard

(1R,9S)-β-Hydrastine hydrochloride
Empirical Formula (Hill Notation):
C21H21NO6 · HCl
CAS Number:
Molecular Weight:
MDL number:
PubChem Substance ID:
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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Tyrosine hydroxylase inhibitor. Reduces dopamine content in PC12 cells.


Unit quantity: 25 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.


Other Notes

Sales restrictions may apply.
Certificate of Analysis
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James A Douglas et al.
Fitoterapia, 81(7), 925-928 (2010-06-17)
Seasonal variations in biomass and alkaloid contents of goldenseal (Hydrastis canadensis) were investigated. Five-year-old plants gave 5x the yield of roots and rhizomes of two-year-old plants, and summer growth gave significant increases in root biomass but not rhizomes. Berberine contents...
E A Abourashed et al.
Journal of pharmaceutical sciences, 90(7), 817-822 (2001-07-18)
Goldenseal (Hydrastis canadensis L., Ranunculaceae) is an ingredient of various dietary supplements intended for enhancing general body immunity. Many goldenseal products are currently available in the United States, either alone or in combination with echinacea. In most products, the content...
Catherine E McNamara et al.
Journal of natural products, 67(11), 1818-1822 (2004-12-01)
A new compound, 5-O-(4'-[beta-d-glucopyranosyl]-trans-feruloyl)quinic acid (GPFQ, 10), is reported from the medicinal plant goldenseal (Hydrastis canadensis). A new HPLC method is described and used to show that GPFQ is a potential marker for goldenseal roots (1.0% w/w) and rhizomes (2.3%)....
Michelle L Dawes et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 880(1), 114-118 (2011-12-20)
A screening method was developed to extract and detect berberine and hydrastine alkaloids from goldenseal root powder and urine samples using HPLC with UV detection. The isocratic method was developed to detect alkaloids in 5 mL of urine prior to...
David J Edwards et al.
Journal of the American Pharmacists Association : JAPhA, 43(3), 419-423 (2003-07-03)
To determine the concentration of hydrastine and berberine, the primary alkaloids in herbal products containing goldenseal. Descriptive comparison of 20 products purchased at local pharmacies or health food stores; 17 products were labeled as containing goldenseal root and 3 products...

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