Y0001553

Ciclesonide

European Pharmacopoeia (EP) Reference Standard

Empirical Formula (Hill Notation):
C32H44O7
CAS Number:
Molecular Weight:
540.69
MDL number:
NACRES:
NA.24
Pricing and availability is not currently available.

biological source

synthetic

grade

pharmaceutical primary standard

Agency/Method

EP

form

neat

CofA

certificate is enclosed in each package

packaging

pkg of 150 mg

mfr. no.

EDQM

storage condition

protect from light

color

white

bp

665.0 °C/1.333 hPa (1229.0°F)

mp

209-211 °C (408—412°F)

solubility

water: <0.1 g/L
acetone: soluble
ethanol: soluble

density

1.23 g/cm3 at 20 °C (1.333 hPa)

Featured Industry

Pharmaceutical (small molecule)

format

neat

shipped in

ambient

storage temp.

2-8°C

SMILES string

CC@@12C(CCC@3(H)C@2(H)C@@H(O)CC@@4(C)C@@3(H)CC@5(H)C@4(OC@@(C6CCCCC6)(H)O5)C(COC(C(C)C)=O)=O)=CC(C=C1)=O

InChI

1S/C32H44O7/c1-18(2)28(36)37-17-25(35)32-26(38-29(39-32)19-8-6-5-7-9-19)15-23-22-11-10-20-14-21(33)12-13-30(20,3)27(22)24(34)16-31(23,32)4/h12-14,18-19,22-24,26-27,29,34H,5-11,15-17H2,1-4H3/t22-,23-,24-,26+,27+,29+,30-,31-,32+/m0/s1

InChI key

LUKZNWIVRBCLON-GXOBDPJESA-N

Looking for similar products? Visit Product Comparison Guide

General description

Ciclesonide is a new-generation, non-halogenated glucocorticoid. It is a prodrug that releases an active primary metabolite, ciclesonide−active principle (CIC-AP), on enzymatic cleavage.
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the
issuing Pharmacopoeia.

Application

Ciclesonide EP reference standard is used as a pharmaceutical primary standard to quantify the analyte in pharmaceutical formulations, bulk drug and metered-dose inhalers (MDIs) and dry powder ciclesonide inhalers using liquid chromatography (LC) based techniques.

Packaging

Unit quantity: 150 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Caution

Other Notes

Sales restrictions may apply.

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
RP-HPLC method for simultaneous estimation of formoterol fumarate, tiotropium bromide and ciclesonide in pharmaceutical metered dose inhalers
Pulla RP, et al.
Asian Journal of Research in Chemistry, 4(4), 585-590 (2011)
New Drugs for Asthma, Allergy and COPD, 42, 42-54 (2001)
Sensitive LC method for simultaneous determination of ciclesonide and formoterol fumarate in dry powder inhaler
Patil AT, et al.
Journal of Liquid Chromatography and Related Technologies, 34(15), 1568-1577 (2011)
Population pharmacokinetics and pharmacodynamics of ciclesonide
Rohatagi S, et al.
Journal of Clinical Pharmacology, 43(4), 365-378 (2003)
Forced degradation study to develop and validate stability-indicating RP-LC method for the determination of ciclesonide in bulk drug and metered dose inhalers
Elkady EF and Fouad MA
Talanta, 87, 222-229 (2011)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service

Social Media

LinkedIn icon
Twitter icon
Facebook Icon
Instagram Icon

MilliporeSigma

Research. Development. Production.

We are a leading supplier to the global Life Science industry with solutions and services for research, biotechnology development and production, and pharmaceutical drug therapy development and production.

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. All Rights Reserved.

Reproduction of any materials from the site is strictly forbidden without permission.