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Y0001599

Wedelolactone

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1,8,9-Trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one, 7-Methoxy-5,11,12-trihydroxycoumestan

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Pack SizeSKUAvailabilityPrice
15 mg
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$154.00

About This Item

Empirical Formula (Hill Notation):
C16H10O7
CAS Number:
Molecular Weight:
314.25
NACRES:
NA.24
PubChem Substance ID:
UNSPSC Code:
41116107
MDL number:

$154.00


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grade

pharmaceutical primary standard

API family

wedelolactone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

COc1cc(O)c-2c(OC(=O)c3c-2oc4cc(O)c(O)cc34)c1

InChI

1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3

InChI key

XQDCKJKKMFWXGB-UHFFFAOYSA-N

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Wedelolactone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). Wedelolactone has no effects on p38 MAP kinase or Akt.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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grade

pharmaceutical primary standard

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grade

primary reference standard

grade

pharmaceutical primary standard

manufacturer/tradename

EDQM

manufacturer/tradename

-

manufacturer/tradename

PhytoLab

manufacturer/tradename

USP

format

neat

format

-

format

-

format

neat

application(s)

pharmaceutical (small molecule)

application(s)

-

application(s)

-

application(s)

pharmaceutical (small molecule)

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

API family

wedelolactone

API family

-

API family

-

API family

scopoletin


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pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1



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Natalia Machado Tavares et al.
The Journal of infectious diseases, 210(4), 656-666 (2014-03-19)
Neutrophils are rapidly recruited to the site of Leishmania infection and play an active role in capturing and killing parasites. They are the main source of leukotriene B4 (LTB4), a potent proinflammatory lipid mediator. However, the role of LTB4 in



Global Trade Item Number

SKUGTIN
Y000159904061833808849

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