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04269

Sigma-Aldrich

Sodium phosphate monobasic dihydrate

meets analytical specification of Ph. Eur., BP, USP, FCC, E 339, 98-100.5% (calc. to the dried substance)

Synonym(s):
Sodium dihydrogen phosphate dihydrate
Linear Formula:
NaH2PO4 · 2H2O
CAS Number:
Molecular Weight:
156.01
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.25

Quality Level

assay

98-100.5% (calc. to the dried substance)

form

powder or crystals

quality

meets analytical specification of Ph. Eur., BP, USP, FCC, E 339

impurities

heavy metals (as Pb), complies
organic volatile impurities, complies
reducing matter, complies
related substances, complies
residual solvents, complies
≤0.2% water-insoluble matter

loss

21.5-24.0% loss on drying, 130 °C

pH

4.1-5.0 (20 °C, 1%)
4.2-4.5 (20 °C, 5%)

anion traces

chloride (Cl-): ≤50 mg/kg
fluoride (F-): ≤10 mg/kg
sulfate (SO42-): ≤200 mg/kg

cation traces

Al:, in accordance
As: ≤1 mg/kg
Ca: ≤20 mg/kg
Ca:, in accordance
Cd: ≤1 mg/kg
Cu: ≤10 mg/kg
Fe: ≤5 mg/kg
Hg: ≤1 mg/kg
Mg: ≤20 mg/kg
Pb: ≤4 mg/kg
Zn: ≤10 mg/kg

suitability

complies for appearance of solution

SMILES string

O.O.[Na+].OP(O)([O-])=O

InChI

1S/Na.H3O4P.2H2O/c;1-5(2,3)4;;/h;(H3,1,2,3,4);2*1H2/q+1;;;/p-1

InChI key

VBJGJHBYWREJQD-UHFFFAOYSA-M

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Application

Sodium phosphate monobasic dihydrate has been used for preparing phosphate buffer solution. It has also been used as a mobile phase for high-performance liquid chromatography.

Biochem/physiol Actions

Sodium phosphate monobasic also referred to as sodium dihydrogen phosphate is a chemical reagent possesses high buffering capacity and is used for preparing biological buffers. It was used as a phosphate supplement for determining whether phosphate supplementation can prevent rickets in very low birth weight infants with prenatal deficiency of phosphate.

Storage Class Code

11 - Combustible Solids

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Funian Zhao et al.
Journal of chromatography. A, 1055(1-2), 109-114 (2004-11-25)
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P C Holland et al.
Lancet (London, England), 335(8691), 697-701 (1990-03-24)
A preliminary study showed that placental histology was abnormal for babies who subsequently had rickets. The findings--low plasma phosphate concentration; maximum percentage tubular reabsorption of phosphate; and high urinary calcium loss--are those of renal conservation of phosphate in the presence...
Eva Bittrich et al.
Biointerphases, 5(4), 159-167 (2011-01-12)
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L Escuder-Gilabert et al.
Journal of chromatography. A, 1363, 331-337 (2014-07-22)
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