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13433

Sigma-Aldrich

Sodium bicarbonate

puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E500, 99.0-100.5%, powder

Synonym(s):
Sodium hydrogen carbonate
Linear Formula:
NaHCO3
CAS Number:
Molecular Weight:
84.01
Beilstein:
4153970
EC Number:
MDL number:
eCl@ss:
38020213
PubChem Substance ID:

Quality Level

grade

puriss.

assay

99.0-100.5%

form

powder

quality

meets analytical specification of Ph. Eur., BP, USP, FCC, E500

impurities

ammonia (NH3), in accordance
organic volatile impurities, complies
residual solvents, complies
water-insoluble matter, complies
≤0.002% ammonium (NH4), complies

loss

≤0.2% loss on drying (silica gel)

pH

≤8.6 (20 °C, 5%)

pKa (25 °C)

(1) 6.37, (2) 10.25 (carbonic acid)

density

2.16 g/mL at 25 °C (lit.)

anion traces

carbonate (CO32-): in accordance
chloride (Cl-): ≤100 mg/kg
sulfate (SO42-): ≤100 mg/kg

cation traces

Al: ≤0.5 mg/kg
As: ≤2 mg/kg
Ca: ≤100 mg/kg
Fe: ≤10 mg/kg
Hg: ≤1 mg/kg
K: ≤100 mg/kg
Pb: ≤2 mg/kg

suitability

complies for appearance of solution

SMILES string

[Na+].OC([O-])=O

InChI

1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1

InChI key

UIIMBOGNXHQVGW-UHFFFAOYSA-M

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Application

Sodium bicarbonate may be involved in the fabrication of silica based monolith columns which can be used in capillary electrochromatography. It can also be used to maintain the pH of the column for the separation of proteins via ion exchange displacement chromatography.

Packaging

1, 5, 4×5 kg in poly bottle

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Use of the sodium salt of poly (vinylsulfonic acid) as a low-molecular-weight displacer for protein separations by ion-exchange displacement chromatography
Jen D.C.S and Pinto.GN
Journal of Chromatography A, 519(1), 87-98 (1990)
Silica-based monoliths for capillary electrochromatography: Methods of fabrication and their applications in analytical separations
Allen D and Rassi EZ
Electrophoresis, 24, 3962-3976 (2003)
Shay P McGuinness et al.
Critical care medicine, 41(7), 1599-1607 (2013-05-21)
Cardiac surgery-associated acute kidney injury occurs in up to 50% of patients and is associated with increased mortality and morbidity. This study aimed to discover if perioperative urinary alkalinization with sodium bicarbonate infusion reduces the prevalence of cardiac surgery-associated acute
Sophia Zoungas et al.
Annals of internal medicine, 151(9), 631-638 (2009-11-04)
Intravenous sodium bicarbonate has been proposed to reduce the risk for contrast-induced nephropathy (CIN). To determine the effect of sodium bicarbonate on the risk for CIN. MEDLINE, PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from 1950 to
Eric A J Hoste et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 25(3), 747-758 (2009-08-26)
There have been conflicting reports on the use of intravenous administration of sodium bicarbonate for prevention of contrast-induced acute kidney injury (CI-AKI). The aim of this study was to evaluate the use of sodium bicarbonate for prevention of CI-AKI. This

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