Sodium hydrosulfite

technical grade

Sodium dithionite, Sodium hypodisulfite
Linear Formula:
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:
Pricing and availability is not currently available.


technical grade

Quality Level


≥82.5% (iodometric)




7-9 (20 °C, 50 g/L)


water: soluble(lit.)

cation traces

heavy metals: ≤ 0.002%

SMILES string




InChI key


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General description

Sodium hydrosulfite (Sodium dithionite, Sodium hypodisulfite, Na2S2O4) is a white crystalline sodium salt. It decomposes in the presence of atmospheric oxygen to afford sodium hydrogen sulfate. It has been prepared by reducing sodium hydrogen sulfite in sulfurous acid solution with zinc. It is widely used for the decolorization prior to dyeing of cloths in the textile industry.


Sodium hydrosulfite may be employed as a reducing agent for the reduction of graphite oxide in a study.
Sodium hydrosulfite has been used as a fluorescent quenching agent in the encapsulation of polynucleotides via production of asymmetric nanoparticles. It has also be used in the form of buffer for the elution of probe labelled proteins involved in the indentification of cellular targets of covalent kinase inhibitors via mass spectrometry method (MS).


5, 100 g in glass bottle
2 kg in glass bottle


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Signal Word


Hazard Statements

Supp Hazards


Hazard Codes


Risk Statement


Safety Statement



UN 1384 4.2 / PGII

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis
Certificate of Origin
  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

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    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

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  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the solubility of Product 157953, Sodium hydrosulfite?

    According to the chemicals encyclopedia published by the Royal Society of Chemistry, 12th ed., Entry# 8771, this compound is very soluble in water, and only slightly in alcohol.

  6. What other species may be present in Product 157953, Sodium hydrosulfite?

    Sigma-Aldrich does not test for the presence or absence of impurities in this product..

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E Gabriele Panarelli et al.
Physical chemistry chemical physics : PCCP, 22(17), 9487-9493 (2020-04-22)
We report on a novel approach to the study of rates and short-lived intermediates of (bio)chemical reactions that involve paramagnetic species. Temperature-cycle Electron Paramagnetic Resonance (EPR) concerns the repeated heating of a reaction mixture in the cavity of an EPR...
A chemoproteomic method for identifying cellular targets of covalent kinase inhibitors
Chen C-Y and Zhang C
Genes & Cancer, 7, 148-148 (2016)
Evaluation of asymmetric liposomal nanoparticles for encapsulation of polynucleotides
Whittenton J, et al.
Langmuir, 24(16), 8533-8540 (2008)
The preparation of high performance and conductive poly (vinyl alcohol)/graphene nanocomposite via reducing graphite oxide with sodium hydrosulfite.
Zhou T, et al.
Composites Science and Technology, 71(9), 1266-1270 (2011)
Ashutosh Upadhyay et al.
ACS chemical biology, 13(9), 2498-2507 (2018-08-10)
MenJ, annotated as an oxidoreductase, was recently demonstrated to catalyze the reduction (saturation) of a single double bond in the isoprenyl side-chain of mycobacterial menaquinone. This modification was shown to be essential for bacterial survival in J774A.1 macrophage-like cells, suggesting...

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