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27221

Sigma-Aldrich

Acetic acid

glacial, puriss., 99-100%

Synonym(s):

Glacial acetic acid

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1 L
$785.00
4 X 5 L
$1,470.00

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Available to ship onMay 15, 2025Details

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1 L
$785.00
4 X 5 L
$1,470.00

About This Item

Linear Formula:
CH3CO2H
CAS Number:
64-19-7
Molecular Weight:
60.05
Beilstein/REAXYS Number:
506007
EC Number:
200-580-7
MDL number:
MFCD00036152
UNSPSC Code:
12352106
PubChem Substance ID:
329752985
NACRES:
NA.21

$785.00

Available to ship onMay 15, 2025Details

Request a Bulk Order

vapor density

2.07 (vs air)

Quality Level

100

grade

puriss.

assay

99-100%

form

liquid

autoignition temp.

800 °F

expl. lim.

16 %, 92 °F
4 %, 59 °F

technique(s)

mass spectrometry (MS): suitable

impurities

≤0.0005% heavy metals (as Pb)
≤0.005% non-volatile matter

refractive index

n20/D 1.371 (lit.)

pH

2.5 (20 °C, 50 g/L)

bp

117-118 °C (lit.)

mp

16.2 °C (lit.)

density

1.04 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤5 mg/kg
sulfate (SO42-): ≤5 mg/kg

cation traces

Fe: ≤5 mg/kg

SMILES string

[F2C(F2C)13F3C]C(O)=O

InChI

1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)

InChI key

QTBSBXVTEAMEQO-UHFFFAOYSA-N

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General description

Acetic acid is an organic carboxylic acid. It is a hygroscopic liquid having pungent odor. Its anhydrous form is commonly referred as glacial acetic acid. It forms dimers linked by hydrogen bonds in solution and gaseous phases. It is weakly acidic in nature.[1]

Application

Acetic acid is widely employed as solvent for various oxidation reactions.[1] It has been used in the analysis of synthetic peptides by electron transfer dissociation (ETD) tandem mass spectrometry (MS/MS).[2] It may be used in the preparation of peroxyacetic acid (disinfectant), via reaction with perhydrol (30% hydrogen peroxide).[1]

Other Notes

The article number 27221-6X1L will be discontinued. Please order the single bottle 27221-1L which is physically identical with the same exact specifications.

pictograms

FlameCorrosion
GHS02,GHS05

signalword

Danger

hcodes

H226,H314

Hazard Classifications

Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

102.2 °F - closed cup

flash_point_c

39 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
STBL1195
STBK4722
STBJ4682
STBJ0364
STBH0410

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John E P Syka et al.
Proceedings of the National Academy of Sciences of the United States of America, 101(26), 9528-9533 (2004-06-24)
Peptide sequence analysis using a combination of gas-phase ion/ion chemistry and tandem mass spectrometry (MS/MS) is demonstrated. Singly charged anthracene anions transfer an electron to multiply protonated peptides in a radio frequency quadrupole linear ion trap (QLT) and induce fragmentation
Eagleson M.
Concise Encyclopedia Chemistry, 5-5 (1994)
Katharine Trenholme et al.
Antimicrobial agents and chemotherapy, 58(7), 3666-3678 (2014-04-16)
Therapies to prevent transmission of malaria parasites to the mosquito vector are a vital part of the global malaria elimination agenda. Primaquine is currently the only drug with such activity; however, its use is limited by side effects. The development
Isabelle Brunet et al.
The Journal of clinical investigation, 124(7), 3230-3240 (2014-06-18)
Autonomic sympathetic nerves innervate peripheral resistance arteries, thereby regulating vascular tone and controlling blood supply to organs. Despite the fundamental importance of blood flow control, how sympathetic arterial innervation develops remains largely unknown. Here, we identified the axon guidance cue
Xianbao Deng et al.
The New phytologist, 201(4), 1469-1483 (2013-11-26)
• Chalcone synthase (CHS) is the key enzyme in the first committed step of the flavonoid biosynthetic pathway and catalyzes the stepwise condensation of 4-coumaroyl-CoA and malonyl-CoA to naringenin chalcone. In plants, CHS is often encoded by a small family
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Questions

  1. Which ascidic acid is best fro extraction buffers?

    1 answer

    1. Extraction buffers are typically used for sample preparation. One would probably want to use a high-purity (> 99 %) acetic acid that has also been tested to make sure that it is low in common impurities. Product 27221 or Product 338826 are relatively reasonable for application.

      Please see the product below:
      https://www.sigmaaldrich.com/product/sigald/338826

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