All Photos(1)

31437

Sigma-Aldrich

Sodium bicarbonate

puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.7%

Synonym(s):
Sodium hydrogen carbonate
Linear Formula:
NaHCO3
CAS Number:
Molecular Weight:
84.01
Beilstein:
4153970
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.85

Quality Level

grade

ACS reagent
puriss. p.a.

Agency/Method

reag. Ph. Eur.

assay

≥99.7%

form

powder

impurities

≤0.0005% ammonium (NH4)
≤0.003% S-compounds (as SO4)
≤0.005% I red. matters (as SO2)
≤0.015% in water insoluble matters

pH

≤8.6 (20 °C, 5%)

pKa (25 °C)

(1) 6.37, (2) 10.25 (carbonic acid)

solubility

H2O: 0.5 g/10 mL, clear, colorless
water: soluble 50 g/L

density

2.16 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤10 mg/kg
phosphate (PO43-): ≤10 mg/kg

cation traces

As: 2 ppm (MHS-AAS)
Ca: ≤100 ppm
Cd: ≤5 ppm
Co: ≤50 ppm
Cu: ≤5 ppm
Fe: ≤5 ppm
K: ≤50 ppm
Mg: ≤50 ppm
Ni: ≤50 ppm
Pb: ≤5 ppm
Zn: ≤5 ppm
heavy metals: ≤5 ppm (by ICP-OES)

suitability

complies for appearance of solution

SMILES string

[Na+].OC([O-])=O

InChI

1S/CH2O3.Na/c2-1(3)4;/h(H2,2,3,4);/q;+1/p-1

InChI key

UIIMBOGNXHQVGW-UHFFFAOYSA-M

Looking for similar products? Visit Product Comparison Guide

General description

Sodium bicarbonate is widely used as a physiological buffer. The pKa for bicarbonate ↔ carbonic acid reaction is 6.37. The pKa for bicarbonate ↔ carbonate reaction is 10.25.

Application

Sodium bicarbonate may be used to maintain 7.4pH in Iscove′s modified Dulbecco′s medium for growth of murine hybridoma cell culture. It may be employed as a component of RPMI-1640 liquid medium in a study.

Certificate of Analysis

Certificate of Origin

D W Denning et al.
The Journal of antimicrobial chemotherapy, 40(3), 401-414 (1997-10-24)
Given the increased choice of therapeutic agents and the rising incidence of serious invasive disease, it is important that reliable in-vitro methods for detecting antifungal drug resistance in Aspergillus spp. are developed. Six clinical isolates of Aspergillus fumigatus, obtained from
S S Ozturk et al.
Biotechnology and bioengineering, 39(4), 418-431 (1992-02-20)
The influence of ammonia and lactate on cell growth, metabolic, and antibody production rates was investigated for murine hybridoma cell line 163.4G5.3 during batch culture. The specific growth rate was reduced by one-half in the presence of an initial ammonia
Sophia Zoungas et al.
Annals of internal medicine, 151(9), 631-638 (2009-11-04)
Intravenous sodium bicarbonate has been proposed to reduce the risk for contrast-induced nephropathy (CIN). To determine the effect of sodium bicarbonate on the risk for CIN. MEDLINE, PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials from 1950 to
Eric A J Hoste et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 25(3), 747-758 (2009-08-26)
There have been conflicting reports on the use of intravenous administration of sodium bicarbonate for prevention of contrast-induced acute kidney injury (CI-AKI). The aim of this study was to evaluate the use of sodium bicarbonate for prevention of CI-AKI. This
Shay P McGuinness et al.
Critical care medicine, 41(7), 1599-1607 (2013-05-21)
Cardiac surgery-associated acute kidney injury occurs in up to 50% of patients and is associated with increased mortality and morbidity. This study aimed to discover if perioperative urinary alkalinization with sodium bicarbonate infusion reduces the prevalence of cardiac surgery-associated acute

Articles

Selective Growth Media for Differentiation and Detection of Escherichia coli and Other Coliforms

An article concerning selective growth media for differentiation and detection of Escherichia coli and other coliforms.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service