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319902

Ethyl acetate

ACS reagent, ≥99.5%

Ethyl acetate

Synonym(s):

EtOAc

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500 mL

Available to ship onMay 06, 2026fromMILWAUKEE

$85.50
1 L

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$98.90
2.5 L

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$164.00
4 L

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$242.00
6 x 1 L

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$492.00
4 x 4 L

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$671.00
4 x 4 L

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$790.00
18 L

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$845.00
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$4,680.00

About This Item

Linear Formula:
CH3COOC2H5
CAS Number:
Molecular Weight:
88.11
UNSPSC Code:
12352108
NACRES:
NA.21
PubChem Substance ID:
EC Number:
205-500-4
Beilstein/REAXYS Number:
506104
MDL number:
Assay:
≥99.5%
Grade:
ACS reagent
Bp:
76.5-77.5 °C (lit.)
Vapor pressure:
73 mmHg ( 20 °C)

$85.50


Available to ship onMay 06, 2026Details


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grade

ACS reagent

Quality Level

agency

suitable for EPA ACB B21-02, suitable for EPA ACB B23-05b

vapor density

3 (20 °C, vs air)

vapor pressure

73 mmHg ( 20 °C)

assay

≥99.5%

form

liquid

autoignition temp.

801 °F

expl. lim.

2.2-11.5 %, 38 °F

dilution

(for analytical testing)

impurities

H2SO4, passes test (darkened), ≤0.0009 meq/g Titr. acid, ≤0.200% water

evapn. residue

≤0.0030%

color

APHA: ≤10

refractive index

n20/D 1.3720 (lit.)

bp

76.5-77.5 °C (lit.)

mp

−84 °C (lit.)

density

0.902 g/mL at 25 °C (lit.)

format

neat

SMILES string

CCOC(C)=O

InChI

1S/C4H8O2/c1-3-6-4(2)5/h3H2,1-2H3

InChI key

XEKOWRVHYACXOJ-UHFFFAOYSA-N

General description

Ethyl acetate ACS grade solvent meets or exceeds the high standards of the American Chemical Society (ACS). It is ideal for most research needs and delivers replicable, publishable results.
Ethyl acetate ACS grade solvent used in:      
  • Routine chemical synthesis      
  • Drying & purification     
  • Critical labware cleaning

Our premium ACS solvents are ideal for routine chemical synthesis, drying, purification, and critical labware cleaning. They meet or exceed the rigorous standards of the American Chemical Society (ACS), ensuring high-quality results for your research needs.

Premium ACS Solvents: Our solvents meet or exceed the stringent standards set by the American Chemical Society, ensuring high quality and reliability for your laboratory applications.

Replicable and Publishable Results: Designed for consistency, our solvents deliver results that can be reliably reproduced, making them ideal for research that requires publication.

Versatile Applications: Suitable for routine chemical synthesis, drying, purification, and critical labware cleaning, our solvents cater to a wide range of research needs in the laboratory.

Application

Ethyl acetate (ACS grade) can be used as a solvent in the synthesis of 6-O-acetyl glycosides via selective acetylation of carbohydrates in the presence of a catalytic amount of sulfuric acid. 6-O-acetyl glycoside derivatives are applicable as precursors for the synthesis of complex oligosaccharides.

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This Item
676810437549EX0240
Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

assay

≥99.5%

assay

≥99.5%

assay

≥99.5%

assay

≥99.5% (GC)

grade

ACS reagent

grade

ACS reagent

grade

ACS reagent

grade

ACS reagent, reagent grade

form

liquid

form

liquid

form

liquid

form

liquid

bp

76.5-77.5 °C (lit.)

bp

76.5-77.5 °C (lit.)

bp

76.5-77.5 °C (lit.)

bp

76.5-77.5 °C (lit.)

impurities

H2SO4, passes test (darkened), ≤0.200% water, ≤0.0009 meq/g Titr. acid

impurities

H2SO4, passes test, ≤0.0009 meq/g Titr. acid, ≤0.2% water

impurities

H2SO4, passes test (darkened), ≤0.0009 meq/g Titr. acid, ≤0.2% water

impurities

≤0.0009 meq/g Titrable acid, ≤0.2% Water (H2O)


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pictograms

FlameExclamation mark

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

target_organs

Central nervous system

supp_hazards

Storage Class

3 - Flammable liquids

flash_point_f

24.8 °F - closed cup

flash_point_c

-4 °C - closed cup



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A green and regioselective acetylation of thioglycoside with ethyl acetate
Liang Pi-Hui, et al.
Tetrahedron Letters, 51(52), 6928-6931 (2010)
Elif Burcu Bali et al.
Asian Pacific journal of tropical biomedicine, 4(7), 505-514 (2014-09-04)
To investigate the in vitro antimicrobial potential of Thermopsis turcica Kit Tan, Vural & Küçüködük against periodontopathogenic bacteria, its antioxidant activity and cytotoxic effect on various cancer cell lines. In vitro antimicrobial activities of ethanol, methanol, ethyl acetate (EtAc), n-hexane
Quinn P Peterson et al.
Nature protocols, 5(2), 294-302 (2010-02-06)
This protocol describes the gram-scale solution-phase synthesis of the colorimetric caspase-3/7 substrate Ac-DEVD-pNA. The caspase enzymes are integral to cellular inflammation and apoptotic cascades, and are commonly studied by cell biologists, medicinal chemists and chemical biologists. In particular, the assessment



Global Trade Item Number

SKUGTIN
319902-20L04061826694930
319902-6X1L04061837565489
319902-2.5L04061826694923
319902-4L04061826694947
319902-4X4L-PB04061826694961
319902-18L-P1-BL04061838691606
319902-4X4L04061826694954
319902-1L04061826694916
319902-18L-CS04061826694886
319902-200L-P204061838161468
319902-500ML04061826694985

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. What methods or procedures should be followed to perform the measurements of 'Residue on Evaporation' and 'Titratable Acid', as outlined in the COA for product 319902?

    1 answer
    1. For an MQ 200 quality level product, it is typically not possible to share test methods. However, in the case of an ACS grade product, one can refer directly to the available ACS monograph.
      The monograph provides specific instructions for conducting the residue on evaporation test, which involves evaporating 40.0 g (45.0 mL) of the sample to dryness in a tared, preconditioned dish on a hot plate (~100 °C). Subsequently, the residue is dried at 105 °C for a duration of 30 minutes.
      Regarding the titratable acid test, the monograph advises adding 0.10 mL of phenolphthalein indicator solution to 10 mL of ethyl alcohol and neutralizing it with 0.01 N sodium hydroxide. Then, 9.0 g (10.0 mL) of the sample should be added, gently mixed, and titrated with 0.01 N sodium hydroxide until the pink color persists for 15 seconds. The requirement is that the usage of sodium hydroxide should not exceed 0.80 mL.

      Helpful?

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