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319937

N,N-Dimethylformamide

ACS reagent, ≥99.8%

Synonym(s):

DMF, NSC 5356

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500 mL

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$146.00
1 L

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$307.00
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200 L

Estimated to ship onJune 02, 2026fromSHEBOYGAN FALLS

$3,250.00

About This Item

Linear Formula:
HCON(CH3)2
CAS Number:
68-12-2
Molecular Weight:
73.09
UNSPSC Code:
12352111
NACRES:
NA.07
PubChem Substance ID:
329753939
EC Number:
200-679-5
Beilstein/REAXYS Number:
605365
MDL number:
MFCD00003284
Assay:
≥99.8%
Grade:
ACS reagent
Bp:
153 °C (lit.)
Vapor pressure:
2.7 mmHg ( 20 °C)

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grade

ACS reagent

Quality Level

200

vapor density

2.5 (vs air)

vapor pressure

2.7 mmHg ( 20 °C)

assay

≥99.8%

form

liquid

autoignition temp.

833 °F

expl. lim.

15.2 %

dilution

(for analytical testing)

impurities

≤0.0005 meq/g Titr. acid, ≤0.003 meq/g Titr. base, ≤0.15% water

evapn. residue

≤0.005%

color

clear, APHA: ≤15

refractive index

n20/D 1.430 (lit.)

pH

7 (20 °C, 200 g/L)

bp

153 °C (lit.)

mp

−61 °C (lit.)

density

0.944 g/mL (lit.)

SMILES string

[H]C(=O)N(C)C

InChI

1S/C3H7NO/c1-4(2)3-5/h3H,1-2H3

InChI key

ZMXDDKWLCZADIW-UHFFFAOYSA-N

General description

N, N-Dimethylformamide (DMF) is an organic compound commonly used as a reagent as well as a solvent in organic synthesis. It plays multiple roles in various reactions such as formylating agent, dehydrating agent, reducing agent as well as a catalyst.
Our premium ACS solvents are ideal for routine chemical synthesis, drying, purification, and critical labware cleaning. They meet or exceed the rigorous standards of the American Chemical Society (ACS), ensuring high-quality results for your research needs.

Premium ACS Solvents: Our solvents meet or exceed the stringent standards set by the American Chemical Society, ensuring high quality and reliability for your laboratory applications.

Replicable and Publishable Results: Designed for consistency, our solvents deliver results that can be reliably reproduced, making them ideal for research that requires publication.

Versatile Applications: Suitable for routine chemical synthesis, drying, purification, and critical labware cleaning, our solvents cater to a wide range of research needs in the laboratory.

Application

DMF can be used as:     
  • A formylating agent for organometallic compounds.
  • A reactant to prepare Vilsmeier reagent by reacting with phosphorus oxychloride.
  • A reagent for amination of aryl chlorides in the presence of potassium t-butoxide.     
  • A reducing agent for metal salts to prepare metal colloids.
  • A catalyst for the regioselective silylation of unprotected carbohydrates.

DMF can also be used in the following:     
  • DMF-Phosgene catalytic system is used to prepare alkyl halides from alcohols.      
  • DMF-POCl3 is used to convert acyclic and cyclic enolizable ketones to β-chloro-α, β-unsaturated aldehydes.
  • DMF-POCl3 is used to synthesize quinoline-3-carbaldehydes from acylanilides.      
  • DMF-SOCl2 combination is used to dehydrate oximes to nitriles.      
  • DMF-Ag2O converts α-bromopropionamides to oxazolidinones.
  • DMF is frequently used as a solvent in many chemical reactions, which require a high solvency power.

Solvent for many hydrophobic organic compounds.

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N,N-Dimethylformamide ACS reagent, ≥99.8%

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Sigma-Aldrich

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Supelco

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grade

ACS reagent

grade

ACS reagent

grade

ACS reagent, puriss. p.a.

grade

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

assay

≥99.8%

assay

≥99.8%

assay

≥99.8% (GC)

assay

≥99.8% (GC)

form

liquid

form

liquid

form

liquid

form

liquid

vapor pressure

2.7 mmHg ( 20 °C)

vapor pressure

2.7 mmHg ( 20 °C)

vapor pressure

2.7 mmHg ( 20 °C)

vapor pressure

2.7 mmHg ( 20 °C)

impurities

≤0.0005 meq/g Titr. acid, ≤0.15% water, ≤0.003 meq/g Titr. base

impurities

≤0.0005 meq/g Titr. acid, ≤0.003 meq/g Titr. base, ≤0.15% water

impurities

≤0.003% free acid (as CH3COOH), ≤0.005% free alkali (as NH3), ≤0.005% non-volatile matter, ≤0.1% water (Karl Fischer)

impurities

≤0.0005 meq/g Titrable acid, ≤0.003 meq/g Titrable base, ≤0.15% Water (H2O), ≤10 ppm Free amine (as dimethylamine)

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Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B

Storage Class

3 - Flammable liquids

wgk

WGK 2

flash_point_f

135.5 °F - closed cup

flash_point_c

57.5 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
SHBT6022
SHBT6013
MKDB3767
MKCZ8645
SHBT7343

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Global Trade Item Number

SKUGTIN
319937-18L-CS04061837910692
319937-1L04061826695074
319937-2.5L04061837565557
319937-200L04061838161475
319937-20L04061837910708
319937-20L-P204061838626646
319937-4L04061837565564
319937-6X1L04061837565595
319937-4L-KC04061838596895
319937-4X4L04061837565571
319937-4X4L-PB04061837565588
319937-500ML04061826695081
319937-56L-P1-LS04061838226891

Questions

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  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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