puriss. p.a., ACS reagent, reag. Ph. Eur., ≥99.8% (GC)

DMF, NSC 5356
Linear Formula:
CAS Number:
Molecular Weight:
Beilstein/REAXYS Number:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level


ACS reagent
puriss. p.a.


reag. Ph. Eur.

vapor density

2.5 (vs air)

vapor pressure

2.7 mmHg ( 20 °C)


≥99.8% (GC)



autoignition temp.

833 °F

expl. lim.

15.2 %


≤0.003% free acid (as CH3COOH)
≤0.005% free alkali (as NH3)
≤0.005% non-volatile matter
≤0.1% water (Karl Fischer)


APHA: ≤15

refractive index

n20/D 1.4290-1.4310
n20/D 1.430 (lit.)


7 (20 °C, 200 g/L)


152-154 °C
153 °C (lit.)


−61 °C (lit.)


0.948-0.950 g/mL at 20 °C
0.944 g/mL (lit.)

cation traces

Al: ≤0.5 mg/kg
B: ≤0.02 mg/kg
Ba: ≤0.1 mg/kg
Bi: ≤0.1 mg/kg
Ca: ≤0.5 mg/kg
Cd: ≤0.05 mg/kg
Co: ≤0.02 mg/kg
Cr: ≤0.02 mg/kg
Cu: ≤0.02 mg/kg
Fe: ≤0.1 mg/kg
K: ≤0.5 mg/kg
Li: ≥0.1 mg/kg
Mg: ≤0.1 mg/kg
Mn: ≤0.02 mg/kg
Mo: ≤0.1 mg/kg
Na: ≤1 mg/kg
Ni: ≤0.02 mg/kg
Pb: ≤0.1 mg/kg
Sn: ≤0.1 mg/kg
Sr: ≤0.1 mg/kg
Zn: ≤0.1 mg/kg

SMILES string




InChI key


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General description

N,N-Dimethylformamide (DMF) is commonly employed as a solvent for various organic reactions. DMF is a useful solvent employed for the isolation of chlorophyll from plant tissues. It is widely employed reagent in organic synthesis. It plays multiple roles in various reactions such as solvent, dehydrating agent, reducing agent as well as catalyst. It is a multipurpose building block for the synthesis of compounds containing O, -CO, -NMe2, -CONMe2, -Me, -CHO as functional groups.


N,N-Dimethylformamide (DMF) may be employed as a solvent in the following studies:
  • Extraction of chlorophyll containing pigments from the intact tissues of cotyledons of Cucumis sativus.
  • Isolation of chlorophyll a from the cell cultures of unicellular marine algae.4
  • As reducing agent and solvent for the preparation of Au@Ag core-shell nanocrystals.
Solvent for many hydrophobic organic compounds.


2.5 L also available in PE-bottles

Other Notes

The article number 33120-4X2.5L-M will be discontinued. Please order the single bottle 33120-2.5L-M which is physically identical with the same exact specifications.
The article number 33120-4X2.5L-R will be discontinued. Please order the single bottle 33120-2.5L-R which is physically identical with the same exact specifications.
The article number 33120-6X1L-M will be discontinued. Please order the single bottle 33120-1L-M which is physically identical with the same exact specifications.
The article number 33120-6X1L-R will be discontinued. Please order the single bottle 33120-1L-R which is physically identical with the same exact specifications.

Signal Word



Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B


3 - Flammable liquids

WGK Germany


Flash Point(F)

135.5 °F - closed cup

Flash Point(C)

57.5 °C - closed cup

Certificate of Analysis

Certificate of Origin

R Moran et al.
Plant physiology, 65(3), 478-479 (1980-03-01)
Photosynthetic pigments from etiolated cucumber (Cucumis sativus var. Beit Alpha improved, Hazera Co., Gedera) cotyledons were extracted by direct immersion of the intact cotyledons into the solvent N,N-dimethylformamide (DMF). The solvent is especially efficient when pigment concentration is low; time...
Shape-dependent evolution of Au@ Ag core- shell nanocrystals by PVP-assisted N,N-dimethylformamide reduction.
Tsuji M, et al.
Crystal Growth & Design, 8(7), 2528-2536 (2008)
W P Inskeep et al.
Plant physiology, 77(2), 483-485 (1985-02-01)
We found inconsistencies in the commonly used data for chlorophyll analysis in 80% acetone. Recently developed extinction coefficients for chlorophyll b in N,N-dimethylformamide (DMF) based on values from 80% acetone are low as a result of these inconsistencies. We determined...
Kun Liu et al.
Nanoscale, 4(20), 6574-6580 (2012-09-15)
Studies on the self-assembly of metal nanoparticles (NPs) in the presence of ions are motivated by the biosensing applications of NP clusters and the capability to control the morphology of clusters of oppositely charged NPs. The effect of ions has...
L Piazza et al.
Nature communications, 6, 6407-6407 (2015-03-03)
Surface plasmon polaritons can confine electromagnetic fields in subwavelength spaces and are of interest for photonics, optical data storage devices and biosensing applications. In analogy to photons, they exhibit wave-particle duality, whose different aspects have recently been observed in separate...

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