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345547

Sigma-Aldrich

Hydrogen chloride solution

4.0 M in dioxane

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Empirical Formula (Hill Notation):
HCl
CAS Number:
Molecular Weight:
36.46
MDL number:
PubChem Substance ID:
NACRES:
NA.21

form

liquid

Quality Level

concentration

3.80-4.40 M (by NaOH, titration)
4.0 M in dioxane

density

1.05 g/mL at 25 °C

SMILES string

Cl

InChI

1S/ClH/h1H

InChI key

VEXZGXHMUGYJMC-UHFFFAOYSA-N

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This Item
455180294837304174
vibrant-m

345547

Hydrogen chloride solution

vibrant-m

455180

Hydrogen chloride solution

vibrant-m

294837

Hydrogen chloride solution

vibrant-m

304174

Hydrogen chloride solution

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

200

form

liquid

form

liquid

form

liquid

form

liquid

density

1.05 g/mL at 25 °C

density

0.747 g/mL at 25 °C

density

0.731 g/mL at 25 °C

density

1.092 g/mL at 25 °C

General description

Hydrogen chloride solution contains 4.0 M hydrogen chloride in 1,4-dioxane as the solvent. It is commonly used as a deprotection reagent during the deprotection of the tert-butoxycarbonyl (Boc) group of various amino acids and peptides. Additionally, it serves as a reagent in various organic synthesis reactions, including the synthesis of N-9-Fluorenylmethoxycarbonyl- (Fmoc) amino-acid chlorides.

Application

Hydrogen chloride solution (4.0 M in dioxane) can be used as:     
  • A reagent for the deprotection of the N-Boc protecting group from various heterocyclic derivatives.     
  • A reagent for the deprotection of polymer protecting groups. For instance, deprotection of benzyl ether-protected polymer.      
  • A polymerization initiator in combination with ZnCl2 in the synthesis of formyl terminated poly(ethyl vinyl ether) from ethyl vinyl ether (EVE).

signalword

Danger

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

supp_hazards

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

62.6 °F - closed cup

flash_point_c

17 °C - closed cup


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