34865

Sigma-Aldrich

Tetrahydrofuran

inhibitor-free, suitable for HPLC, ≥99.9%

Synonym(s):
Tetramethylene oxide, THF, Oxolane, Butylene oxide
Empirical Formula (Hill Notation):
C4H8O
CAS Number:
Molecular Weight:
72.11
Beilstein/REAXYS Number:
102391
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

Quality Level

vapor density

2.5 (vs air)

vapor pressure

114 mmHg ( 15 °C)
143 mmHg ( 20 °C)

assay

≥99.9%

form

liquid

autoignition temp.

610 °F

expl. lim.

1.8-11.8 %

application(s)

HPLC: suitable

impurities

≤0.0005% non-volatile matter
≤0.002% free acid (as CH3COOH)
≤0.05% peroxides (as H2O2)
≤0.05% water (Karl Fischer)

evapn. residue

≤0.0005%

color

APHA: ≤10

refractive index

n20/D 1.407 (lit.)

pH

~7

bp

65-67 °C (lit.)

mp

−108 °C (lit.)

density

0.889 g/mL at 25 °C (lit.)

absorption

≤0.0044 at 315 nm
≤0.005 at 350 nm
≤0.005 at 400 nm
≤0.02 at 300 nm
≤0.046 at 275 nm
≤0.18 at 250 nm
≤0.26 at 245 nm
≤1.0 at 212 nm

UV absorption

λ: 245 nm Amax: ≤0.26
λ: 275 nm Amax: ≤0.046
λ: 315 μm Amax: ≤0.0044

suitability

complies for IR spectroscopy

Featured Industry

Food and Beverages

SMILES string

C1CCOC1

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChI key

WYURNTSHIVDZCO-UHFFFAOYSA-N

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General description

Tetrahydrofuran (THF) is widely employed as a solvent. It constitutes the key fragment of various natural products (polyether antibiotics). THF forms a double hydrate with hydrogen sulfide. Crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies. Butane-1,4-diol is formed as an intermediate during the synthesis of THF. Hot THF is useful for the dissolution of polyvinylidene chloride (PVDV).

Application

Suitable for HPLC, spectrophotometry, environmental testing
Tetrahydrofuran may be used for the dissolution of poly-ε-caprolactone (PCL) and 1,3-diaminopentane, during the preparation of poly-ε-caprolactone (PCL)-hydroxyapatite (HA) scaffolds and acrylate-terminated poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32)- 1,3-diaminopentane (117) polymer, respectively.

Packaging

1, 6×1, 2, 4×2.5, 4, 4×4 L in glass bottle
20 L in Nowpak™
200 L in Pure-Pac™ 1
100, 12×100 mL in glass bottle

Other Notes

Important notice
  • The article number 34865-4X2.5L will be discontinued. Please order the single bottle 34865-2.5L which is physically identical with the same exact specifications.
  • The article number 34865-6X1L will be discontinued. Please order the single bottle 34865-1L which is physically identical with the same exact specifications.

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Signal Word

Danger

hazcat

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2

Supp Hazards

EUH019

storage_class_code

3 - Flammable liquids

WGK Germany

WGK 1

Flash Point(F)

-6.2 °F - closed cup

Flash Point(C)

-21.2 °C - closed cup

Certificate of Analysis

Certificate of Origin

Haiying Yu et al.
Biomaterials, 30(4), 508-517 (2008-11-01)
Natural bone growth greatly depends on the precedent vascular network that supplies oxygen and essential nutrients and removes metabolites. Likewise, it is crucial for tissue-engineered bone to establish a vascular network that temporally precedes new bone formation, and spatially originates...
Polyhedral clathrate hydrates. X. Structure of the double hydrate of tetrahydrofuran and hydrogen sulfide.
Mak TCW, et al.
J. Chem. Phys. , 42(8), 2732-2737 (1965)
Todd J Harris et al.
Biomaterials, 31(5), 998-1006 (2009-10-24)
The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. However, the efficacy of polymeric gene delivery methods is low, particularly in vivo. One significant concern is that the interior and...
Eagleson M.
Concise Encyclopedia Chemistry, 152-152 (1994)
Eagleson M.
Concise Encyclopedia Chemistry, 883-883 (1994)

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