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360481

Sigma-Aldrich

1,4-Dioxane

ACS reagent, ≥99.0%, contains ≤25 ppm BHT as stabilizer

Synonym(s):
Diethylene oxide, Dioxane
Empirical Formula (Hill Notation):
C4H8O2
CAS Number:
Molecular Weight:
88.11
Beilstein:
102551
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

grade

ACS reagent

Quality Level

vapor density

3 (vs air)

vapor pressure

27 mmHg ( 20 °C)
40 mmHg ( 25 °C)

Assay

≥99.0%

form

liquid

autoignition temp.

356 °F

contains

≤25 ppm BHT as stabilizer

expl. lim.

22 %

impurities

≤0.0016 meq/g Titr. acid
≤0.005% Peroxide (as H2O2)
≤0.01% Carbonyl (as HCHO)
≤0.05% water

evapn. residue

≤0.005%

color

APHA: ≤20

refractive index

n20/D 1.422 (lit.)

pH

6.0-8 (20 °C, 500 g/L)

bp

100-102 °C (lit.)

mp

10-12 °C (lit.)

transition temp

freezing point ≥11.0

density

1.034 g/mL at 25 °C (lit.)

SMILES string

C1COCCO1

InChI

1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2

InChI key

RYHBNJHYFVUHQT-UHFFFAOYSA-N

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1 of 4

This Item
6769343485776887
1,4-Dioxane ACS reagent, ≥99.0%, contains ≤25 ppm BHT as stabilizer

Sigma-Aldrich

360481

1,4-Dioxane

1,4-Dioxane ACS reagent, ≥99.0%

Sigma-Aldrich

676934

1,4-Dioxane

1,4-Dioxane suitable for HPLC, ≥99.5%

Sigma-Aldrich

34857

1,4-Dioxane

1,4-Dioxane analytical standard

Supelco

76887

1,4-Dioxane

vapor density

3 (vs air)

vapor density

3 (vs air)

vapor density

3 (vs air)

vapor density

3 (vs air)

vapor pressure

27 mmHg ( 20 °C), 40 mmHg ( 25 °C)

vapor pressure

27 mmHg ( 20 °C), 40 mmHg ( 25 °C)

vapor pressure

27 mmHg ( 20 °C), 40 mmHg ( 25 °C)

vapor pressure

27 mmHg ( 20 °C), 40 mmHg ( 25 °C)

assay

≥99.0%

assay

≥99.0%

assay

≥99.5%

assay

≥99.5% (GC)

form

liquid

form

liquid

form

liquid

form

-

autoignition temp.

356 °F

autoignition temp.

356 °F

autoignition temp.

356 °F

autoignition temp.

356 °F

General description

1,4-Dioxane is a heterocyclic organic compound that is commonly used as a solvent in several chemical reactions. It is also used as a stabilizer in chlorinated solvents.

Application

1,4-Dioxane can be used as:      
  • A solvent in the N-methylation of amines by reductive functionalization of CO2 in the presence of NaBH4 as the reducing reagent.      
  • An additive to synthesize 3-hydroxylisoindolin-1-ones via hydroxylhydrative aza-cyclization of 2-alkynylbenzamide.

A mixture of 1,4-dioxane/ethanol/formic acid solvent system can be used in the depolymerization of lignin to synthesize value-added phenolic monomers.

Signal Word

Danger

Hazard Statements

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

51.8 °F - closed cup

Flash Point(C)

11 °C - closed cup


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