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MilliporeSigma

443778

NMP

ACS reagent, ≥99.0%

Synonym(s):

1-Methyl-2-pyrrolidone, N-Methyl-2-pyrrolidone, NMP

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500 ML

$109.00

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$166.00

2.5 L

$278.00

18 L

$1,280.00

$109.00


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About This Item

Empirical Formula (Hill Notation):
C5H9NO
CAS Number:
Molecular Weight:
99.13
NACRES:
NA.21
PubChem Substance ID:
UNSPSC Code:
12352005
EC Number:
212-828-1
MDL number:
Beilstein/REAXYS Number:
106420
Grade:
ACS reagent
Assay:
≥99.0%
Bp:
202 °C (lit.)
81-82 °C/10 mmHg (lit.)
Vapor pressure:
0.29 mmHg ( 20 °C)
0.99 mmHg ( 40 °C)

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Product Name

1-Methyl-2-pyrrolidinone, ACS reagent, ≥99.0%

InChI key

SECXISVLQFMRJM-UHFFFAOYSA-N

InChI

1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

SMILES string

CN1CCCC1=O

grade

ACS reagent

vapor density

3.4 (vs air)

vapor pressure

0.29 mmHg ( 20 °C)
0.99 mmHg ( 40 °C)

assay

≥99.0%

form

liquid

autoignition temp.

518 °F

expl. lim.

9.5 %

dilution

(for analytical testing)

impurities

≤0.01% Free amines (as CH3NH2)
≤0.05% water

color

APHA: ≤50

refractive index

n20/D 1.47 (lit.)

pH

7.7-10.0 (20 °C, 100 g/L)

bp

202 °C (lit.)
81-82 °C/10 mmHg (lit.)

mp

−24 °C (lit.)

solubility

acetone: miscible(lit.)
alcohol: miscible(lit.)
benzene: miscible(lit.)
chloroform: miscible(lit.)
ethyl acetate: miscible(lit.)
water: miscible(lit.)

density

1.028 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤1 ppm

Quality Level

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1 of 4

This Item
5.89597328634270458
assay

≥99.0%

assay

99.5%

assay

99.5%

assay

≥99%

grade

ACS reagent

grade

anhydrous

grade

anhydrous

grade

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

solubility

acetone: miscible(lit.), benzene: miscible(lit.), ethyl acetate: miscible(lit.), alcohol: miscible(lit.), water: miscible(lit.), chloroform: miscible(lit.)

solubility

-

solubility

-

solubility

-

form

liquid

form

-

form

liquid

form

liquid

mp

−24 °C (lit.)

mp

−24 °C (lit.)

mp

−24 °C (lit.)

mp

−24 °C (lit.)

Application

1-Methyl-2-pyrrolidinone may be used as:
  • An alternative eluent to THF in the size exclusion chromatography (SEC) based resolution of coal-derived liquids.[1]
  • Reaction medium to prepare 2-aryl and 2-alkyl benzothiazoles.[2]
  • A solvent in the ultrasonic preparation of metal organic framework (MOF-177) crystals.[3]
It may be used to synthesize single-phase chalcopyrite CuInSe2 nanocrystals[4] and potassium 3-methyl-2-oxo-pyrrolidinenitronate.[5]

General description

Our premium ACS solvents are ideal for routine chemical synthesis, drying, purification, and critical labware cleaning. They meet or exceed the rigorous standards of the American Chemical Society (ACS), ensuring high-quality results for your research needs.

Premium ACS Solvents: Our solvents meet or exceed the stringent standards set by the American Chemical Society, ensuring high quality and reliability for your laboratory applications.

Replicable and Publishable Results: Designed for consistency, our solvents deliver results that can be reliably reproduced, making them ideal for research that requires publication.

Versatile Applications: Suitable for routine chemical synthesis, drying, purification, and critical labware cleaning, our solvents cater to a wide range of research needs in the laboratory.

pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

195.8 °F - Pensky-Martens closed cup

flash_point_c

91 °C - Pensky-Martens closed cup


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A Green and Air Pressure Solution Synthesis of CuInSe2 Nanocrystals Using 1-methyl-2-Pyrrolidinone as Hot Solvent.
Wang W, et al.
Journal of the American Ceramic Society. American Ceramic Society, 94(8), 2571-2577 (2011)
Alkyl nitrate nitration of active methylene-compounds. 15. Nitration of 1-methyl-4-piperidone, 1-methyl-2-pyrrolidinone and 1,3-dimethyl-2-pyrrolidinone.
Feuer H, et al.
Journal of Heterocyclic Chemistry, 16(3), 481-485 (1979)
Solubility limitations in the determination of molecular mass distributions of coal liquefaction and hydrocracking products: 1-methyl-2-pyrrolidinone as mobile phase in size exclusion chromatography.
Herod AA, et al.
Energy and Fuels, 10(3), 743-750 (1996)
Aneuploidy induction in Saccharomyces cerevisiae by two solvent compounds, 1-methyl-2-pyrrolidinone and 2-pyrrolidinone.
Mayer VW, et al.
Environmental and Molecular Mutagenesis, 11(1), 31-40 (1988)
1-Methyl-2-pyrrolidinone: A well-adapted solvent in the benzothiazoles synthesis.
Brembilla A, et al.
Synthetic Communications, 20(21), 3379-3384 (1990)

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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