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455180

Sigma-Aldrich

Hydrogen chloride solution

2.0 M in diethyl ether

Empirical Formula (Hill Notation):
HCl
CAS Number:
Molecular Weight:
36.46
MDL number:
PubChem Substance ID:
NACRES:
NA.21

form

liquid

Quality Level

concentration

1.90-2.20 M (with NaOH, titration)
2.0 M in diethyl ether

bp

34.6 °C

density

0.747 g/mL at 25 °C

storage temp.

2-8°C

SMILES string

Cl

InChI

1S/ClH/h1H

InChI key

VEXZGXHMUGYJMC-UHFFFAOYSA-N

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1 of 4

This Item
345547304174294837
concentration

1.90-2.20 M (with NaOH, titration), 2.0 M in diethyl ether

concentration

3.80-4.40 M (by NaOH, titration), 4.0 M in dioxane

concentration

1.0 M in acetic acid, 950-1100 mmol/L (silver nitrate titration)

concentration

0.95-1.10 M (with NaOH, titration), 1.0 M in diethyl ether

bp

34.6 °C

bp

-

bp

-

bp

-

density

0.747 g/mL at 25 °C

density

1.05 g/mL at 25 °C

density

1.092 g/mL at 25 °C

density

0.731 g/mL at 25 °C

storage temp.

2-8°C

storage temp.

-

storage temp.

-

storage temp.

2-8°C

Quality Level

100

Quality Level

200

Quality Level

-

Quality Level

100

General description

The product is a 2M solution of hydrogen chloride in diethyl ether.

Application

Hydrogen chloride solution can be used as a reagent to synthesize:
  • Cyanohydrin alkyl ethers via chiral Bronsted acid-mediated hydrocyanation of vinyl ethers with silyl cyanides.
  • N, N-Dimethylaniline hydrochloride salts via Pd-catalyzed Buchwald-Hartwig amination of aryl triflates with dimethylamines.
It can also be used as a catalyst for the amidation of carboxylic acids with amines to synthesize amides.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 1 - Met. Corr. 1 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

-29.2 °F - closed cup

Flash Point(C)

-34 °C - closed cup


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