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571261

Sigma-Aldrich

Piperidine

biotech. grade, ≥99.5%

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Synonym(s):
Hexahydropyridine
Empirical Formula (Hill Notation):
C5H11N
CAS Number:
Molecular Weight:
85.15
Beilstein/REAXYS Number:
102438
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

grade

biotech. grade

Quality Level

vapor density

3 (vs air)

vapor pressure

23 mmHg ( 20 °C)

assay

≥99.5%

form

liquid

technique(s)

DNA sequencing: suitable

impurities

<0.3% water

refractive index

n20/D 1.452 (lit.)

bp

106 °C (lit.)
106 °C

mp

−13 °C (lit.)

solubility

organic solvents: soluble(lit.)
water: miscible(lit.)

density

0.862 g/mL at 20 °C (lit.)

λ

1 cm path, H2O reference

UV absorption

λ: 290 Amax: <1.000
λ: 370 Amax: <0.050

SMILES string

C1CCNCC1

InChI

1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2

InChI key

NQRYJNQNLNOLGT-UHFFFAOYSA-N

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1 of 4

This Item
104094W290820411027
Piperidine biotech. grade, &#8805;99.5%

571261

Piperidine

Piperidine ReagentPlus&#174;, 99%

104094

Piperidine

Piperidine &#8805;99%, FG

W290820

Piperidine

Piperidine &#8805;99.5%, purified by redistillation

411027

Piperidine

assay

≥99.5%

assay

99%

assay

≥99%

assay

≥99.5%

grade

biotech. grade

grade

-

grade

FG, Halal, Kosher

grade

-

solubility

organic solvents: soluble(lit.), water: miscible(lit.)

solubility

organic solvents: soluble(lit.), water: miscible(lit.)

solubility

-

solubility

-

form

liquid

form

-

form

-

form

liquid

technique(s)

DNA sequencing: suitable

technique(s)

-

technique(s)

-

technique(s)

-

General description

Piperidine, a heterocyclic cyclohexane is a volatile secondary amine. Maxam-Gilbert chemical method, a DNA sequencing technology employs piperidine to rupture DNA strands at damaged base site. Its crystal structure analyzed at 150K shows hydrogen bonding between NH groups. Piperidine ring forms a part of many naturally occuring alkaloids. It is prepared on an industrial scale by the hydrogenation of pyridine in the presence of nickel catalyst. The 1H NMR spectrum of piperidine has been recorded.

application

Fits Applied Biosystems 431 and 433A peptide synthesizers.
Piperidine has been used in combination with DMF (dimethylformamide) for the removal of Fmoc (fluorenylmethyloxycarbonyl) group from the N-terminal amino group during peptide synthesis.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

60.8 °F - closed cup

flash_point_c

16 °C - closed cup


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Peptide Synthesis.
Miao Z and Cheng Z
Bio-protocol, 2(14) (2012)
W B Mattes et al.
Biochimica et biophysica acta, 868(1), 71-76 (1986-10-16)
The volatile, secondary amine piperidine is used in the Maxam-Gilbert chemical method of DNA sequencing to create strand breaks in DNA at sites of damaged bases. As such it is often used in generalized studies of DNA damage to identify
Andrew Parkin et al.
Acta crystallographica. Section B, Structural science, 60(Pt 2), 219-227 (2004-03-16)
The crystal structures of piperazine, piperidine and morpholine have been determined at 150 K. All three structures are characterized by the formation of NH...N hydrogen-bonded chains. In piperazine these are linked to form sheets, but the chains are shifted so
Total synthesis of (-)-kopsinine by an asymmetric one-pot [n+2+3] cyclization.
Shingo Harada et al.
Chemistry, an Asian journal, 7(10), 2196-2198 (2012-08-22)
Marek Łuczkowski et al.
Inorganic chemistry, 47(23), 10875-10888 (2008-10-31)
A de novo protein design strategy provides a powerful tool to elucidate how heavy metals interact with proteins.Cysteine derivatives of the TRI peptide family (Ac-G(LKALEEK)4G-NH2) have been shown to bind heavy metals in an unusual trigonal geometry. Our present objective

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