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Cyclopentyl methyl ether

greener alternative

contains 50 ppm BHT as inhibitor, ReagentPlus®, ≥99.90%

Empirical Formula (Hill Notation):
CAS Number:
Molecular Weight:
MDL number:
PubChem Substance ID:

Quality Level

product line







50 ppm BHT as inhibitor

greener alternative product characteristics

Safer Solvents and Auxiliaries
Learn more about the Principles of Green Chemistry.


≤50 ppm H2O2


106 °C/760 mmHg


-140 °C


0.86 g/mL at 25 °C

greener alternative category


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InChI key


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General description

We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. Cyclopentyl methyl ether (CPME) is a greener alternative to other ethereal solvents such as tetrahydrofuran (THF), 2-methyl tetrahydrofuran (2-MeTHF), dioxane (carcinogenic), tert-Butyl methyl ether (MTBE), and 1,2-dimethoxyethane (DME) and thus has been enhanced for "Safer Solvents and Auxiliaries". Click here for more information.
CPME is a greener alternative solvent for many aprotic ether solvents. It has many properties which make it safer and greener alternative:
  • High boiling point
  • Clean organic-water phase separation
  • Reduced energy to recover

It also is safer for use, with a lower peroxide formation than either THF or 2-MeTHF.


Greener alternative solvent in reactions containing the following reagents:
  • Alkali agents
  • Lewis acid-mediated reactions
  • Organometallic
  • Reduction and Oxidation
  • Transition metal catalysts
  • Azeotropic water removal

Can also be used in extraction, polymerization, crystallization and surface coatings.

The toxicological assessment of cyclopentyl methyl ether (CPME) as a green solvent.


500 mL in glass bottle
1, 6×1, 4, 4×4 L in glass bottle
18, 200 L in steel drum

Features and Benefits

Replacement for THF, diethyl ether and DMSO.

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC


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Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2

Storage Class Code

3 - Flammable liquids

WGK Germany


Flash Point(F)

37.4 °F - closed cup

Flash Point(C)

< 3 °C - closed cup

Certificate of Analysis

Certificate of Origin

  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

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  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

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Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents
MacMillan, D.S.; et al.
Green Chemistry (2012)
Cyclopentyl Methyl Ether as a New and Alternative Process Solvent
Watanabe, K.; Yamagiwa, N.; Torisawa, Y.
Organic Process Research & Development, 11 (2007)
Rikako Takahiro et al.
Biological & pharmaceutical bulletin, 38(1), 58-65 (2015-03-07)
The aim of this study was to characterize the kinetics of metabolite formation of the phosphodiesterase type-5 (PDE5) inhibitors sildenafil and tadalafil by CYP3A4, CYP3A5, and CYP3A7 isoforms. The formations of N-desmethyl sildenafil and desmethylene tadalafil were examined using CYP3A...

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