Copper(II) sulfate pentahydrate

ReagentPlus®, ≥98.0%

Sulfuric acid, copper(II) salt (1:1) pentahydrate, Blue Vitriol, Cupric sulfate pentahydrate
Linear Formula:
CuSO4 · 5H2O
CAS Number:
Molecular Weight:
EC Number:
MDL number:
PubChem Substance ID:

Quality Level

vapor pressure

7.3 mmHg ( 25 °C)

product line





powder or crystals


3.7-4.5 (25 °C, 50 g/L)


110 °C (dec.) (lit.)

cation traces

Fe: ≤ 0.01%

SMILES string




InChI key


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General description

Copper(II) sulfate is an inorganic Lewis acid commonly used to promote acid?catalyzed organic reactions. It is used as a reagent for the synthesis of copper carbenoids. It can also act as an effective redox catalyst in combination with other mixed oxidizing systems.


250, 500 g in poly bottle
1 kg in poly bottle

Legal Information

ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC

Signal Word


Hazard Statements


Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1


13 - Non Combustible Solids

WGK Germany


Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Copper(II) Sulfate
Encyclopedia of Reagents for Organic Synthesis, Second Edition (2016)
Bárbara Acosta-Iborra et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(5), 6654-6674 (2020-03-31)
Angiogenesis, the main mechanism that allows vascular expansion for tissue regeneration or disease progression, is often triggered by an imbalance between oxygen consumption and demand. Here, by analyzing changes in the transcriptomic profile of endothelial cells (ECs) under hypoxia we...
Bhagwan S Batule et al.
International journal of nanomedicine, 10 Spec Iss, 137-142 (2015-09-09)
We developed a simple but efficient method to synthesize protein-inorganic hybrid nanostructures with a flower-like shape (nanoflowers), which relies on sonication to facilitate the synthesis of the nanoflowers. With this technique, we synthesized nanoflowers containing laccase as a model protein...
Gabriela M B Haverroth et al.
Ecotoxicology and environmental safety, 122, 440-447 (2015-09-20)
Copper is a heavy metal found at relatively high concentrations in surface waters around the world. Copper is a micronutrient at low concentrations and is essential to several organisms. At higher concentrations copper can become toxic, which reveal the importance...
Yan Wang et al.
Pharmaceutical research, 31(11), 3106-3119 (2014-05-23)
Although Cu complexes have been investigated as anticancer agents, there has been no description of Cu itself as a cancer killing agent. A stealth liposomal Cu formulation (LpCu) was studied in vitro and in vivo. LpCu was evaluated in prostate...

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