02286

Sigma-Aldrich

Kollidon® 25

Synonym(s):
PVP, Povidone, Polyvinylpyrrolidone, Polyvidone
Linear Formula:
(C6H9NO)n
CAS Number:
MDL number:
NACRES:
NA.25

Quality Level

application(s)

sample preservation: suitable

impurities

≤1 ppm hydrazine
≤10 ppm heavy metals (verified on random samples only)
≤10 ppm lead (verified on random samples only)
≤10 ppm vinylpyrrolidinone
≤3.0% 2-pyrrolidone
≤400 ppm peroxides (as H2O2)
≤5.0% water
≤500 ppm aldehydes (as acetaldehyde)
≤5000 ppm formic acid
12.0-12.8% nitrogen (anhydrous basis)

ign. residue

≤0.1% (verified on random samples only)

pH

3.0-5.0

suitability

complies for Infrared spectrum

InChI

1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2

InChI key

WHNWPMSKXPGLAX-UHFFFAOYSA-N

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Application

The Kollidon products consist of soluble and insoluble grades of polyvinylpyrrolidone (PVP) of various molecular weights and particle sizes. It is used as dry binders, film-formers, stabilizers in suspensions, dispersants for pigments, enzyme stabilisiers and bioavailablility improvers.
Kollidon SR is a blend of polyvinyl acetate and povidone (K 30) in the ratio 8:2 for use as matrix-forming agent. This research grade product is intended for use in R&D and development only.

Other Notes

Polyvinylpyrrolidone is a component of Denhardt′s Solution and is included at a concentration of 1% (w/v) in the standard 50X stock solution.

Legal Information

Kollidon is a registered trademark of BASF SE

RIDADR

NONH for all modes of transport

WGK Germany

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificate of Analysis

Certificate of Origin

Yan-Yan Yin et al.
Inorganic chemistry, 51(8), 4784-4790 (2012-03-31)
Chiral Ni(II) coordination compounds with structures of [NiL(H(2)O)(3)] (1) and {[NiL(H(2)O)]·0.5H(2)O}(n) (2) (H(2)L = thiazolidine 2,4-dicaboxlic acid) have been successfully synthesized by the reaction of Ni(CH(3)COO)(2)·4H(2)O and H(2)L in aqueous solution at 25 and 80 °C, respectively. From the same...
Jianxin Zhang et al.
International journal of pharmaceutics, 414(1-2), 210-217 (2011-06-02)
Nanothermal analysis (NTA) supported by atomic force microscopy imaging has been used to study the changes that occur at the surfaces of solid dispersions of the drug felodipine and the water soluble polymer, polyvinylpyrrolidone (PVP) on exposure to standard pharmaceutical...
Camila Braga Dornelas et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 14(1), 17-35 (2011-04-20)
This work describes the preparation of new nanocomposites based on lamellar silicates (AAM-alkyl ammonium montmorillonite) obtained by the intercalation of PVP K30 and glyceril monostearate. By XRD, TGA and DSC analysis the AAM was characterized and its compactation characteristics, functionality...
Ajit S Narang et al.
Journal of pharmaceutical sciences, 101(1), 127-139 (2011-11-24)
Reactive peroxides in povidone often lead to degradation of oxidation-labile drugs. To reduce peroxide concentration in povidone, the roles of storage conditions, antioxidants, and silicates were investigated. Povidone alone and its physical mixtures with ascorbic acid, propyl gallate, sodium sulfite...
Liyun Ren et al.
Nanoscale, 5(6), 2337-2345 (2013-02-09)
PLLA fibrous tissue scaffolds with controlled fiber nanoscale surface roughness are fabricated with a novel centrifugal jet spinning process. The centrifugal jet spinning technique is a highly efficient synthesis method for micron- to nano-sized fibers with a production rate up...

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