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05129

Sigma-Aldrich

L-Alanine

BioUltra, ≥99.5% (NT)

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Synonym(s):
(S)-2-Aminopropionic acid, L-α-Aminopropionic acid
Empirical Formula (Hill Notation):
C3H7NO2
CAS Number:
Molecular Weight:
89.09
Beilstein:
1720248
EC Number:
MDL number:
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26

product line

BioUltra

Assay

≥99.5% (NT)

form

powder or crystals

optical activity

[α]20/D +14.0±1.0°, c = 5% in 5 M HCl

impurities

insoluble matter, passes filter test
≤0.3% foreign amino acids

ign. residue

≤0.05%

loss

≤0.05% loss on drying, 20 °C (HV)

color

colorless to white

pH

5.5-7.0 (25 °C, 1 M in H2O)

mp

314.5 °C

solubility

H2O: 1 M at 20 °C, clear, colorless

anion traces

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

cation traces

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
NH4+: ≤100 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

1 M in H2O

UV absorption

λ: 260 nm Amax: ≤0.03
λ: 280 nm Amax: ≤0.02

application(s)

detection

SMILES string

C[C@H](N)C(O)=O

InChI

1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1

InChI key

QNAYBMKLOCPYGJ-REOHCLBHSA-N

Gene Information

human ... CA1(759) , CA2(760)

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This Item
05130W3818298.16000
L-Alanine BioUltra, ≥99.5% (NT)

Sigma-Aldrich

05129

L-Alanine

Premium Grade
L-Alanine ≥99.0% (NT)

Sigma-Aldrich

05130

L-Alanine

-
L-Alanine ≥99%

Sigma-Aldrich

W381829

L-Alanine

-
(S)-(+)-Alanine for synthesis

Sigma-Aldrich

8.16000

(S)-(+)-Alanine

-
assay

≥99.5% (NT)

assay

≥99.0% (NT)

assay

≥99%

assay

-

form

powder or crystals

form

powder or crystals

form

chunks, crystalline powder

form

solid

optical activity

[α]20/D +14.0±1.0°, c = 5% in 5 M HCl

optical activity

[α]20/D +14.0±1°, c = 5% in 5 M HCl

optical activity

[α]20/D +13.5 to +15.5°, c = 10 in 6 M HCl

optical activity

-

impurities

insoluble matter, passes filter test, ≤0.3% foreign amino acids

impurities

≤0.3% foreign amino acids

impurities

-

impurities

-

color

colorless to white

color

colorless to white

color

-

color

-

Biochem/physiol Actions

Alanine is a nonessential amino acid that plays a key role in the glucose-alanine cycle between muscle tissue and the liver. In amino acid-degrading tissues such as muscle, amino groups are pooled as glutamate by transamination reactions. The amino group of glutamate is transferred to pyruvate via alanine aminotransferase, forming alanine and α-ketoglutarate. The alanine is passed into the blood and transported to the liver. This reaction is reversed in the liver where pyruvate can be used in gluconeogenesis to form glucose, which may return to other tissues through the circulatory system. Increased alanine levels correlate with higher blood pressure, energy intake, cholesterol levels, and body mass index.

Other Notes

Postulated salting-in effect on proteins; Growth requirement of a variety of microorganisms.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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CRC Handbook of Microbiology, 4, 1-1 (1974)
Theory of protein solubility.
T Arakawa et al.
Methods in enzymology, 114, 49-77 (1985-01-01)
Rachelle S Doody et al.
The New England journal of medicine, 369(4), 341-350 (2013-07-26)
Alzheimer's disease is characterized by the presence of cortical amyloid-beta (Aβ) protein plaques, which result from the sequential action of β-secretase and γ-secretase on amyloid precursor protein. Semagacestat is a small-molecule γ-secretase inhibitor that was developed as a potential treatment
Mom Das et al.
Nucleic acids research, 42(6), 3943-3953 (2013-12-29)
Errors in protein synthesis due to mispairing of amino acids with tRNAs jeopardize cell viability. Several checkpoints to prevent formation of Ala- and Cys-tRNA(Pro) have been described, including the Ala-specific editing domain (INS) of most bacterial prolyl-tRNA synthetases (ProRSs) and
J M Rhoads et al.
Journal of pediatric gastroenterology and nutrition, 9(2), 225-231 (1989-08-01)
We studied sodium-dependent uptake of L-alanine into small intestinal brush border membrane vesicles (BBMV) isolated from piglets 40 h after infection with transmissible gastroenteritis (TGE) virus. Vesicles from TGE-infected pigs and uninfected litter-mate controls showed comparable degrees of enrichment and

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