All Photos(2)

107689

Sigma-Aldrich

Hexadimethrine bromide

≥95%

Synonym(s):
Polybrene, 1,5-Dimethyl-1,5-diazaundecamethylene polymethobromide
CAS Number:
MDL number:
NACRES:
NA.26

Quality Level

assay

≥95%

storage temp.

2-8°C

InChI

1S/C10H24N2.C3H6Br2/c1-11(2)9-7-5-6-8-10-12(3)4;4-2-1-3-5/h5-10H2,1-4H3;1-3H2

InChI key

KZKAYEGOIJEWQB-UHFFFAOYSA-N

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Application

Antiheparin agent. A 3mg quantity has been found to enhance peptide degradation in automated sequential analysis.

Packaging

10, 100 g in poly bottle

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US),Eyeshields,Gloves

Certificate of Analysis

Certificate of Origin

G Montalescot et al.
Circulation, 82(5), 1754-1764 (1990-11-01)
Protamine reversal of heparin anticoagulation in patients is occasionally associated with life-threatening acute pulmonary hypertension. In a sheep model, we evaluated the effect on this adverse cardiopulmonary reaction of modifying the type of heparin (low molecular weight heparin compared with...
Noam Auslander et al.
Molecular systems biology, 13(12), 956-956 (2017-12-03)
Metabolic alterations play an important role in cancer and yet, few metabolic cancer driver genes are known. Here we perform a combined genomic and metabolic modeling analysis searching for metabolic drivers of colorectal cancer. Our analysis predicts FUT9, which catalyzes...
Janina R Lange et al.
Biophysical journal, 109(1), 26-34 (2015-07-15)
We describe a method for quantifying the mechanical properties of cells in suspension with a microfluidic device consisting of a parallel array of micron-sized constrictions. Using a high-speed charge-coupled device camera, we measure the flow speed, cell deformation, and entry...
Yujie Zhang et al.
Scientific reports, 7, 41173-41173 (2017-01-24)
Excessive deposition of type I collagen causes fibrotic diseases. Binding of La ribonucleoprotein domain family, member 6 (LARP6) to collagen mRNAs regulates their translation and is necessary for high type I collagen expression. Here we show that mTORC1 phosphorylates LARP6...
Yuji Kondo et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(12), 4714-4719 (2013-03-09)
Although endogenous ligands for Toll-like receptor (TLR)4-myeloid differentiation factor 2 (MD2) have not been well-understood, we here report that a globo-series glycosphingolipid, globotetraosylceramide (Gb4), attenuates the toxicity of lipopolysaccharides (LPSs) by binding to TLR4-MD-2. Because α1,4-galactosyltransferase (A4galt)-deficient mice lacking globo-series...

Articles

Polybrene® Technical Bulletin

Polybrene® is a well-known anti-heparin agent. Also known as 1,5-dimethyl-1,5-diazaundecamethylene polymethobromide and hexadimethrine bromide, this positively charged polymer produces non-specific red blood cell agglutination by neutralizing the red blood cell net negative charge.

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